Results 51 to 60 of about 665,037 (318)
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
The influence of inclusion size and number density on high-temperature urea corrosion (HTUC) behavior of ferritic stainless steels was investigated in a simulated working environment of selective catalytic reduction (SCR) system in commercial vehicles ...
Xuelin Wang +4 more
doaj +1 more source
Flexible physical interfaces [PDF]
Human-computer interface devices are rigid, and afford little or no opportunity for end-user adaptation. This thesis proposes that valuable new interaction possibilities can be generated through the development of user interface hardware that is ...
Villar, Nicolas, Nicolas Villar
core
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Precise control and measurement of the cellular microenvironment, particularly oxygen concentration, are crucial for developing physiologically relevant in vitro models.
Christoph Grün +8 more
doaj +1 more source
Affordance-based Design of Physical Interfaces for Ubiquitous Computing Environments [PDF]
Physical interfaces have been proposed as a way to realize natural interactions with ubiquitous computing environments. The successful design of such interfaces requires design approaches that integrate aspects of our world which are usually treated ...
Gerd Kortuem +3 more
core
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Previous studies on aesthetic chills (i.e., psychogenic shivers) demonstrate their positive effects on stress, pleasure, and social cognition. We tested whether we could artificially enhance this emotion and its downstream effects by intervening on its ...
A. J. H. Haar +3 more
doaj +1 more source

