Results 91 to 100 of about 491,602 (238)
PLoS ONE, 2016 BackgroundHepatitis C virus infection is a global health problem. New direct-acting antiviral agents have been recently approved. However, due to their high cost and some genotypes remaining difficult to treat, interferon-based therapy with pegylated ...
Ran Chen +4 more
doaj +1 more source
Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy
Advanced Healthcare Materials, EarlyView.Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima +15 more
wiley +1 more source
Interferón gamma en el manejo de la enfermedad granulomatosa crónica en el paciente pediátrico
, 2014 Antecedentes: La enfermedad granulomatosa crónica aumenta el riesgo de infecciones. El interferón gamma se ha venido utilizando como parte del tratamiento; sin embargo, su eficacia no ha sido explorada por una revisión sistemática.\ud Objetivo ...
Bohorquez Garnica, Andrés +1 more
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Eficacia y seguridad del tratamiento frente al virus de la hepatitis C con pautas antivirales de acción directa libre de interferón en pacientes coinfectados por el virus de la inmunodeficiencia humana y el virus de la hepatitis C. [PDF]
, 2017 El reciente desarrollo de agentes antivirales de acción directa (AAD) para el tratamiento de la infección por VHC ha demostrado que son fármacos bien tolerados y altamente eficaces en comparación con las terapias anteriores,basadas en interferón.
Hernández Ros, María Rosario
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Anxiety and depression levels in interferon using and non using hepatitis C patients
Psychiatry and Clinical Psychopharmacology, 2021 Objective: This study aims to compare the depression and anxiety levels in interferon using and non-using groups of patients with hepatitis C. Method: In this case control study, 55 Hepatitis C patients of 40 using interferon and 15 nonuser were ...
Mehmet Yumru +5 more
doaj
Advanced Healthcare Materials, EarlyView.Surface‐host dialogue at the implant interface governs biological fate and osseointegration. Surface physicochemical properties of titanium (Ti) dental implants, including microgrooves, nanopatterns, nanotopography, roughness, and wettability, modulate the initial adsorption of proteins and the formation of a dynamic biointerface.
Daniela Moreira Cunha +9 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Gellan gum fluid gel (FG) enables controlled ocular delivery of mesenchymal stromal cell (MSC)‐derived extracellular vesicles (EV). Its shear‐thinning, solid‐liquid‐solid rheology ensures prolonged ocular retention. Sustained MSC‐EV release (∼18% in 6 hrs) supports effective EV ocular delivery.
Seyedmohammad Moosavizadeh +7 more
wiley +1 more source
Tratamiento de la hepatitis viral aguda c con interferón alfa 2b recombinante: Ensayo clínico
, 2000 Se llevó a cabo un ensayo clínico con el objetivo de evaluar la eficacia y la seguridad del interferón en un grupo de 13 pacientes con hepatitis aguda por virus C. Se realizó el diagnóstico siguiendo criterios bioquímicos (alaninoaminotransferasa 2 veces
Guillermo Padrón González +7 more
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Evaluación de los perfiles de respuesta a interferón inducidos como respuesta a la infección con el virus del dengue [PDF]
, 2015 Introducción: El dengue es la principal enfermedad viral transmitida a humanos por artrópodos. Una de las características del cuadro clínico de la infección por el virus del dengue (DENV) es su alta variabilidad en la severidad, pronóstico y resolución ...
Arellanos Soto, Daniel
core
Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities
Advanced Science, EarlyView.ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal +3 more
wiley +1 more source