Results 141 to 150 of about 491,602 (238)

Desarrollo normal del embarazo en dos pacientes con leucemia mieloide crónica tratadas con interferón-a

La leucemia mieloide crónica (LMC) es un trastorno clonal que generalmente se diagnostica con facilidad porque las células leucémicas en más del 95 % de los pacientes presentan una anomalía citogenética característica, el cromosoma Filadelfia (Ph).
María L Telles-Chacón, Onel M Avila-Cabrera, Edgardo Espinosa-Estrada, Leslie González-Pinedo, Carlos Hernández-Padrón, Lissette Izquierdo-Cano, Wilfredo Roque-García, Luis G Ramón-Rodríguez, Gelquin Mustelier-Celza   +8 more
core  

When Treatment Turns to Stone: Injection-Site Calcinosis Associated With Interferon-β in Multiple Sclerosis: A Case Report. [PDF]

Clin Case Rep
Walter A, Bott A, Kiechle M, Hund-Georgiadis M.   +3 more
europepmc   +1 more source

DTX3L Inhibits the EMT, Metastasis, and Stem‐Like Features of Gastric Cancer Through Promoting GSK‐3β Dependent SNAI1 Decay

Advanced Science, EarlyView.
This research identifies DTX3L as a critical tumor suppressor that inhibits epithelial‐mesenchymal transition (EMT), invasion and metastasis in gastric cancer. By functioning as an E3 ubiquitin ligase, DTX3L targets the master EMT regulator SNAI1 for GSK‐3β‐dependent proteasomal degradation.
Yang Chen, Zhen Li, Jiajia Shen, Jingyu Lin, Xiaoli Zhao, Rui Zhang, Ying Han, Zhen Wang   +7 more
wiley   +1 more source

Revisiting down syndrome through the lens of interferonopathy and innate immune dysregulation. [PDF]

Front Immunol
Wang G, Shi W, Liao S, Hao B.
europepmc   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Empleo del Interferón alfa 2b recombinante y ribavirina en la lesión hepática crónica producida por virus C en pacientes no respondedores a la monoterapia.

, 2012
Se realizó un estudio observacional descriptivo, de corte transversal, con el objetivo de describir los resultados y la tolerabilidad de la terapia combinada con interferón  alfa 2b recombinante y ribavirina en el retratamiento de pacientes con lesión ...
Estrada Guerra, Yelec, Camacho Assef, José   +1 more
core  

Subtype-specific functions of basal IFNλs. [PDF]

J Virol
Stanifer ML.
europepmc   +1 more source

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

Comment on: Efficacy and safety of posterior subtenon interferon alfa-2B injection in recurrent inflammatory macular edema. [PDF]

Indian J Ophthalmol
Sahare H, Anupama H.
europepmc   +1 more source

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, EarlyView.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source