Results 51 to 60 of about 744,029 (294)

Estimulación del sistema mediado por interferón tipo I de lenguado senegalés (Solea senegalensis) en respuesta a infecciones por nodavirus [PDF]

, 2014
El lenguado senegalés es susceptible a la infección por el Virus de la Necrosis Nerviosa Viral (VNNV). Los betanodavirus se clasifican en cuatro genotipos, siendo los genotiposSJNNV, RGNNV y virus recombinantes RGNNV-SJNNV los que causan mortalidad en ...
Alonso-Sanchez, Maria del Carmen, Bandín, Isabel, Podadera, AM, Souto, S, Álvarez-Torres, Daniel   +4 more
core  

Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling

Journal of Experimental Medicine, 2020
Heterozygous missense mutations in COPA underlie constitutive interferon signaling through STING, thereby defining a novel type I interferonopathy and emphasizing the importance of the ER–Golgi axis in interferon homeostasis.
A. Lepelley, M. Martin-Niclós, M. Le Bihan, J. Marsh, C. Uggenti, G. Rice, V. Bondet, D. Duffy, Jonny Hertzog, J. Rehwinkel, S. Amselem, Siham Boulisfane-El Khalifi, M. Brennan, Edwin Carter, L. Chatenoud, S. Chhun, Aurore Coulomb l’Hermine, Marine Depp, M. Legendre, K. Mackenzie, J. Marey, C. McDougall, K. McKenzie, T. Molina, B. Neven, L. Seabra, C. Thumerelle, M. Wislez, N. Nathan, N. Manel, Y. Crow, M. Frémond   +31 more
semanticscholar   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Tratamiento de hepatitis C en la insuficiencia renal crónica terminal en hemodiálisis con Interferón 2 b y ribavirina: A case report Treatment of hepatitis C in end-stage chronic renal failure in hemodialysis with Interferon 2 b and ribavirine

Revista Cubana de Medicina, 2005
Se realizó la presentación clínica de un paciente de 32 años con antecedentes de salud hasta los 29 años de edad en que comienza a presentar una insuficiencia renal crónica terminal, se le aplicó tratamiento dialítico inmediatamente y 5 meses después se ...
Yanet Parodis López, Alexis Pérez Rodríguez, Enrique Arus Soler, Francisco Gutiérrez, Orestes Benítez Llanes, Alexander Mármol Sóñora   +5 more
doaj  

Anifrolumab, an Anti–Interferon‐α Receptor Monoclonal Antibody, in Moderate‐to‐Severe Systemic Lupus Erythematosus

Arthritis & Rheumatology, 2017
To assess the efficacy and safety of anifrolumab, a type I interferon (IFN) receptor antagonist, in a phase IIb, randomized, double‐blind, placebo‐controlled study of adults with moderate‐to‐severe systemic lupus erythematosus (SLE).
R. Furie, M. Khamashta, J. Merrill, V. Werth, K. Kalunian, P. Brohawn, G. Illei, J. Drappa, Liangwei Wang, S. Yoo   +9 more
semanticscholar   +1 more source

COVID-19 and emerging viral infections: The case for interferon lambda

Journal of Experimental Medicine, 2020
The Viewpoint discusses the benefits and potential limitations of using interferon lambda (IFN-λ, a type III interferon) to prevent, limit, and treat COVID-19.
L. Prokunina-Olsson, Noémie Alphonse, Ruth E Dickenson, J. Durbin, J. Glenn, R. Hartmann, S. Kotenko, Helen M. Lazear, T. O'Brien, Charlotte Odendall, O. Onabajo, H. Piontkivska, D. Santer, N. Reich, A. Wack, I. Zanoni   +15 more
semanticscholar   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Results of interferon-based treatments in Alaska Native and American Indian population with chronic hepatitis C [PDF]

International Journal of Circumpolar Health, 2016
Background: There have been few reports of hepatitis C virus (HCV) treatment results with interferon-based regimens in indigenous populations. Objective: To determine interferon-based treatment outcome among Alaska Native and American Indian (AN/AI ...
Stephen E. Livingston, Lisa J. Townshend-Bulson, Dana J. T. Bruden, Chriss E. Homan, James E. Gove, Julia N. Plotnik, Brenna C. Simons, Philip R. Spradling, Brian J. McMahon   +8 more
doaj   +1 more source

Terapia del carcinoma de células renales [PDF]

, 2018
El cáncer renal se encuentra entre los 10 tipos de cánceres más diagnosticados a nivel mundial, representando entre el 3-5% de todos los casos diagnosticados. Una detección precoz suele estar asociada con un pronóstico favorable.
Ramírez Sánchez, Pablo
core  

Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood

Journal of Experimental Medicine, 2003
Systemic lupus erythematosus (SLE) is a prototype systemic autoimmune disease characterized by flares of high morbidity. Using oligonucleotide microarrays, we now show that active SLE can be distinguished by a remarkably homogeneous gene expression ...
Lynda Bennett, A. Palucka, Edsel Arce, Edsel Arce, Victoria Cantrell, Victoria Cantrell, J. Borvák, J. Banchereau, Virginia Pascual, Virginia Pascual   +9 more
semanticscholar   +1 more source