Results 61 to 70 of about 104,951 (246)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Group Based Interference Alignment [PDF]

IEEE Communications Letters, 2011
3 pages, 3 figures.
Yanjun Ma, Jiandong Li 0001, Rui Chen 0001, Junliang Yao   +3 more
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Topological Interference Management for MIMO Interference Broadcast Channels

IEEE Access, 2019
In this paper, we investigate the topological interference management (TIM) for MIMO interference broadcast channels (IBC) under the fixed topology, where only topology information is needed to cancel the inter-cell interference (ICI).
Wei Liu, Dan Chen, Jiandong Li, Yinghong Ma   +3 more
doaj   +1 more source

Interference alignment performance in Gaussian interference channel

IET Communications, 2014
Interference alignment (IA) is a data transmission scheme that achieves maximum multiplexing gains in interference channel. This study investigates the theoretical sum rate for IA. By analysing both the asymptotic eigenvalues distribution and the magnitude of the effective channel after interference cancellation in IA, a closed‐form of sum rate ...
Qinmin Wang, Changlin Zhou, Zhongpei Zhang, Fengke Jie   +3 more
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Index Coding—An Interference Alignment Perspective [PDF]

IEEE Transactions on Information Theory, 2012
The index coding problem is studied from an interference alignment perspective, providing new results as well as new insights into, and generalizations of, previously known results. An equivalence is established between multiple unicast index coding where each message is desired by exactly one receiver, and multiple groupcast index coding where a ...
Hamed Maleki, Viveck R. Cadambe, Syed Ali Jafar   +2 more
openaire   +4 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Joint alignment and steering to manage interference

Digital Communications and Networks
In wireless communication networks, mobile users in overlapping areas may experience severe interference, therefore, designing effective Interference Management (IM) methods is crucial to improving network performance.
Zhao Li, Xiujuan Liang, Yinghou Liu, Jia Liu, Zheng Yan   +4 more
doaj   +1 more source