Results 101 to 110 of about 1,835,725 (293)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Interference alignment performance in Gaussian interference channel
IET Communications, 2014 Interference alignment (IA) is a data transmission scheme that achieves maximum multiplexing gains in interference channel. This study investigates the theoretical sum rate for IA. By analysing both the asymptotic eigenvalues distribution and the magnitude of the effective channel after interference cancellation in IA, a closed‐form of sum rate ...
Qinmin Wang +3 more
openaire +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Co-channel and Adjacent Channel Interference Calculations in Cellular Communications Systems
Journal of King Saud University: Engineering Sciences, 2000 Signal to Interference ratio (S/I) calculations for corner excited cellular communications systems based on median mobile-to-base and base-to-mobile signal powers for co-channel interference and immediately adjacent as well as non- immediately adjacent ...
Yousef G. El-Jaafreh
doaj +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
International Journal of Antennas and Propagation, 2014 The challenge of a full-duplex single-channel system is the method to transmit and receive signals simultaneously at the same time and on the same frequency. Consequently, a critical issue involved in such an operation is the resulting self-interference.
Pawinee Meerasri +2 more
doaj +1 more source
On the Achievability of Interference Channel Coding
CoRR, 2022 71 pages (v1) the full version of the paper submitted to IEEE ISIT2022 (v2) typos are corrected, the full version of the paper submitted to 2022 IEICE International Symposium on Information Theory and its Applications (ISITA2022)
openaire +3 more sources
A Cooperative Network Coding Strategy for the Interference Relay Channel. [PDF]
, 2012 In this paper, we study an interference relay network with a satellite as relay. We propose a cooperative strategy based on physical layer network coding and superposition modulation decoding for uni-directional communications among users.
Méric, Hugo +3 more
core +1 more source