The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Degrees of Freedom of a K-User Interference Channel in the Presence of an Instantaneous Relay. [PDF]
Entropy (Basel), 2022 Abdollahi Bafghi AH +2 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Self-Interference Channel Training for Full-Duplex Massive MIMO Systems. [PDF]
Sensors (Basel), 2021 Kim T, Min K, Park S.
europepmc +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Distributed Beamforming and Power Allocation for Heterogeneous Networks with MISO Interference Channel. [PDF]
Sensors (Basel), 2021 Lee K.
europepmc +1 more source
On the Achievable Rates for the Return-Link of Multi-Beam Satellite Systems Using Successive Interference Cancellation [PDF]
, 2011 This paper investigates the theoretically reachable rates in the return-link of multi-user multi-beam satellite systems. The return-link can actually be analyzed by means of multiple-input multiple-output signal processing techniques. While MIMO inspired
Michael Joham +7 more
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Topological Interference Management for K-User Downlink Massive MIMO Relay Network Channel
Sensors, 2017 In this paper, we study the emergence of topological interference alignment and the characterizing features of a multi-user broadcast interference relay channel.
Poongundran Selvaprabhu +3 more
doaj +1 more source