Results 51 to 60 of about 939,916 (257)

Simulation of Multi-element Antenna Systems for Navigation Applications [PDF]

open access: yes, 2007
The application of user terminals with multiple antenna inputs for use with the global satellite navigation systems like GPS and Galileo becomes more and more attraction in last years.
Denks, Holmer   +3 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Interference mitigation techniques in wireless communications systems

open access: yes, 2011
Co-Channel Interference, Intersymbol interference and fading are major impairment to the high-capacity transmission in power- and band-limited wireless communication channel.
Oyedepo, JA   +5 more
core   +1 more source

L-DACS1 Laboratory Demonstrator Development and Compatibility Measurement Set-up [PDF]

open access: yes, 2010
The Future Communications Infrastructure (FCI) comprises a set of data link technologies for aeronautical communications. For the airport, a data link technology dubbed AeroMACS is currently developed within NextGen and SESAR which is strongly based on ...
Franzen, Nico   +5 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Cooperative Downlink Multicell Preprocessing Relying on Reduced-Rate Back-Haul Data Exchange [PDF]

open access: yes, 2011
Different-complexity multicell preprocessing (MCP) schemes employing distributed signal-to-interference leakage-plus-noise ratio (SILNR) precoding techniques are proposed, which require reduced back-haul data exchange in comparison with the conventional ...
Rong Zhang   +3 more
core   +1 more source

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