Results 101 to 110 of about 2,082,160 (325)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Successive Decode-and-Forward Relaying With Privacy-Aware Interference Suppression

IEEE Access, 2020
Successive relaying holds the promise of achieving spatial diversity gain for single-antenna users while recovering the multiplexing loss due to the half-duplex relaying in B5G/6G.
Jianjing Wei, Jie Wei, Shaoling Hu, Wei Chen   +3 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Two-color interference stabilization of atoms

, 2003
The effect of interference stabilization is shown to exist in a system of two atomic levels coupled by a strong two-color laser field, the two frequencies of which are close to a two-photon Raman-type resonance between the chosen levels, with open ...
A. I. Andryushin, A. I. Andryushin, A. I. Andryushin, A. I. Magunov, E. Arimondo, E. Arimondo, G. Alzetta, M. V. Fedorov, M. V. Fedorov, M. V. Fedorov, M. V. Fedorov, N. J. Kylstra, N. P. Poluektov   +12 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Long Short‐Term Memory Network for Co‐Frequency Co‐Time Full‐Duplex Digital Domain Interference Suppression

IET Science, Measurement & Technology
The co‐frequency co‐time full duplex (CCFD) system transmits and receives signals at the same frequency simultaneously, which can effectively improve the communication spectrum utilization of satellite and solve the problem of satellite frequency ...
Yuting Zhang, Chao Ma, Xiaoyan Gao, Yuhan Huang   +3 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Multi-Interference Suppression Network: Joint Waveform and Filter Design for Radar Interference Suppression

Electronics
With the advancement of electromagnetic interference and counter-interference technology, complex and unpredictable interference signals greatly reduce radar detection, tracking, and recognition performance. In multi-interference environments, the overlap of interference cross-correlation peaks can mask target signals, weakening radar interference ...
Rui Cai, Chenge Shi, Wei Dong, Ming Bai
openaire   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A study on electromagnetic interference analysis and suppression method for traction system of high-speed EMU

机车电传动, 2022
According to the complexity of electromagnetic interference of traction system of high-speed EMU, and in combination with the design of the vehicle system, the EMI coupling paths of traction system were analyzed.
YANG Deyong, ZHU Bingquan, CHEN Ying, ZHI Yongjian, YUAN Keliang, YAN Guanglin   +5 more
doaj