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Inhibition of intracellular hepatitis C virus replication by nelfinavir and synergistic effect with interferon-α

Inhibition of intracellular hepatitis C virus replication by nelfinavir and synergistic effect with interferon-α
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The effect of interferon-γ on genetic immunization

Vaccine, 1997
The effect of co-inoculation of a plasmid vector expressing the rabies virus glycoprotein and an additional vector encoding mouse interferon (IFN)-gamma on the development of an antigen specific B and T helper cell response was tested upon intramuscular inoculation of mice. The effect of IFN-gamma was dependent on the promoter driving expression of the
Z Q, Xiang, Z, He, Y, Wang, H C, Ertl
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Cutaneous Necrosis Associated With Interferon α-2b

The American Journal of Gastroenterology, 1998
Cutaneous necrosis may occur as a complication of treatment with interferon. Here we report the first case of cutaneous necrosis developing in a patient receiving interferon α-2b for the treatment of chronic hepatitis C viral infection. The patient developed two necrotic lesions while receiving high doses of interferon.
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Interferon-γ brings additive anti-viral environment when combined with interferon-α in patients with chronic hepatitis C

Hepatology Research, 2002
T-cell hyporesponsiveness may lead to chronicity of hepatitis C virus (HCV) infection. We evaluated whether interferon (IFN)-gamma injection can bring a Th1-dominant environment to patients with chronic hepatitis C. Seventeen patients with genotype 1b received natural IFN-alpha 5MU daily for the first 2 weeks and three times a week for the next 22 ...
Ryukichi, Kumashiro, Tatsuya, Ide, Masaru, Sasaki, Shiro, Murashima, Hiroshi, Suzuki, Teruko, Hino, Yasuyo, Morita, Ichiro, Miyajima, Kei, Ogata, Eisuke, Tanaka, Hiroshi, Yoshida, Kyuichi, Tanikawa, Michio, Sata   +12 more
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High serum level of P-selectin in patients responded to interferon-α treatment for chronic hepatitis C

Hepatology Research, 1998
Abstract Circulating soluble P-selectin levels in sera of patients with chronic hepatitis C treated with natural interferon-α were investigated. Serum soluble P-selectin levels gradually increased after venesection when the sera were incubated at room temperature without serum separation, but the levels did not exceed more than 300 ng ml−1 during 3 h.
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Multifocal osteomyelitis caused by nontuberculous mycobacteria in patients with a genetic defect of the interferon-γ receptor

The Netherlands Journal of Medicine, 2001
We describe three patients with multifocal osteomyelitis caused by Mycobacterium avium and a family history of one or more first degree family members diagnosed with various clinical presentations of infections with nontuberculous mycobacteria. There was a significant delay in the diagnosis and they had a protracted course of their illness, which ...
S M, Arend, R, Janssen, J J, Gosen, H, Waanders, T, de Boer, T H, Ottenhoff, J T, van Dissel   +6 more
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Interstitial Pneumonitis during Combination Therapy with Interferon-α and Ribavirin in a Patient with Chronic Hepatitis C

Zeitschrift für Gastroenterologie, 2002
After nine weeks of combination therapy with recombinant interferon-alpha and ribavirin for chronic hepatitis C a 62-year old woman complained of a dry cough and exertional dyspnea. An elevated erythrocyte sedimentation rate was noticed. Prior to treatment chest X-rays and physical examination revealed no pulmonary abnormalities.
K S, Rothfuss, J C, Bode
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Randomized controlled trial of twice-a-day administration of natural interferon β for chronic hepatitis C

Hepatology Research, 2000
We conducted a randomized controlled trial to assess the efficacy of twice-a-day administration of natural interferon beta (IFNbeta) as an induction of IFN therapy for chronic hepatitis C. Seventy-one patients with chronic hepatitis C were enrolled into the trial and randomly assigned into three treatment groups.
, Yoshioka, , Yano, , Hirofuji, , Arao, , Kusakabe, , Sameshima, , Kuriki, , Kurokawa, , Murase, , Ishikawa, , Kakumu   +10 more
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Genotype, serum level of HCV-RNA and response to interferon-α treatment in patients with chronic hepatitis C

The Netherlands Journal of Medicine, 1995
Since only a small proportion of patients with chronic hepatitis C benefit from interferon therapy, we assessed the viral factors such as HCV genotype and the level of viraemia for prediction of interferon response.HCV genotype and serum levels of HCV-RNA were determined in 24 patients before, during and after interferon treatment.Pre-treatment serum ...
C, Clarysse, C, Van den Eynde, F, Nevens, C, Portier, N, Aelbrecht, J, Fevery, S H, Yap   +6 more
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Interferon-γ Up-regulates Expression of Cysteinyl Leukotriene Type 2 Receptors on Eosinophils in Asthmatic Patients

Chest, 2005
Cysteinyl leukotrienes (cysLTs) are strong bronchoconstrictive mediators that play a key role in asthma inflammation. They act through specific receptors including cysLT type 1 receptor (CysLT1R) and cysLT type 2 receptor (CysLT2R). Although these two receptors are co-expressed on inflammatory cells, little is known about CysLT2R in patients with ...
Masaru, Fujii, Hiroshi, Tanaka, Shosaku, Abe   +2 more
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