Results 1 to 10 of about 304,482 (118)
Biomedicines, 2022 Ovarian cancer (OC) is a particularly lethal disease due to intratumoral heterogeneity, resistance to traditional chemotherapy, and poor response to targeted therapy and immunotherapy.
Qun Liu +9 more
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CD8+ T lymphocyte is a main source of interferon-gamma production in Takayasu’s arteritis
Scientific Reports, 2021 Interferon-gamma (IFN-γ) is a cytokine involved in the pathogenesis of Takayasu’s arteritis (TAK). However, the source of IFN-γ in TAK patients is not fully clear. We aimed to investigate the source of IFN-γ in TAK. 60 TAK patients and 35 health controls
Yan-Long Ren +10 more
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Interferon gamma-dependent intestinal pathology contributes to the lethality in bacterial superantigen-induced toxic shock syndrome. [PDF]
PLoS ONE, 2011 Toxic shock syndrome (TSS) caused by the superantigen exotoxins of Staphylococcus aureus and Streptococcus pyogenes is characterized by robust T cell activation, profound elevation in systemic levels of multiple cytokines, including interferon-γ (IFN-γ),
Ashenafi Y Tilahun +4 more
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Molecular Pain, 2023 Background : Trigeminal nerve injury causes orofacial pain that can interfere with activities of daily life. However, the underlying mechanism remains unknown, and the appropriate treatment has not been established yet.
Sayaka Asano +9 more
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Dysregulation of the IFN-γ-STAT1 signaling pathway in a cell line model of large granular lymphocyte leukemia. [PDF]
PLoS ONE, 2018 T cell large granular lymphocyte leukemia (T-LGLL) is a rare incurable disease that is characterized by defective apoptosis of cytotoxic CD8+ T cells.
Paige M Kulling +6 more
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IFN-γ-induced ER stress impairs autophagy and triggers apoptosis in lung cancer cells
OncoImmunology, 2021 Interferon-gamma (IFN-γ) is a major effector molecule of immunity and a common feature of tumors responding to immunotherapy. Active IFN-γ signaling can directly trigger apoptosis and cell cycle arrest in human cancer cells.
Can Fang +8 more
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Effects of IFN-γ on IL-18 Expression in Pregnant Rats and Pregnancy Outcomes [PDF]
Asian-Australasian Journal of Animal Sciences, 2013 The present study focused on establishing the effects of interferon-gamma (IFN-γ) on interleukin-18 (IL-18) expression patterns and pregnancy outcomes in pregnant rats. Pregnant rats at the post-implantation stage were randomized into control, low IFN-γ (
Li-fang Si +5 more
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Interferon gamma suppresses collagen-induced arthritis by regulation of Th17 through the induction of indoleamine-2,3-deoxygenase. [PDF]
PLoS ONE, 2013 C57BL/6 mice are known to be resistant to the development of collagen-induced arthritis (CIA). However, they show a severe arthritic phenotype when the Ifng gene is deleted.
Jaeseon Lee +11 more
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Interferon-γ acutely augments inhibition of neocortical layer 5 pyramidal neurons
Journal of Neuroinflammation, 2020 Background Interferon-γ (IFN-γ, a type II IFN) is present in the central nervous system (CNS) under various conditions. Evidence is emerging that, in addition to its immunological role, IFN-γ modulates neuronal morphology, function, and development in ...
Gabriel M. S. Janach +7 more
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Frontiers in Medicine, 2023 ObjectiveNeutralizing anti-interferon (IFN)-γ autoantibodies are linked to opportunistic infections (OIs). To explore the association between anti-IFN-γ autoantibodies and OIs in patients with adult-onset Still's disease (AOSD), we aimed to examine the ...
Po-Ku Chen +15 more
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