Results 11 to 20 of about 304,612 (248)

Targeting MDK Abrogates IFN-γ-Elicited Metastasis inCancers of Various Origins

Frontiers in Oncology, 2022
IFN-γ is a pleiotropic cytokine with immunomodulatory and tumoricidal functions. It has been used as an anti-tumor agent in adjuvant therapies for various cancers.
Luyu Zheng, Qun Liu, Ruijun Li, Shibin Chen, Jingyu Tan, Lina Li, Xichen Dong, Changzhi Huang, Tao Wen, Jian Liu, Jian Liu   +10 more
doaj   +1 more source

Monitoring of the Immune Response Activity in Iraqi Patients Infected with Cutaneous Leishmaniasis by IFN-γ and MIG Evaluation During Different Stages of Infection

Iraqi Journal of Science, 2020
Cutaneous leishmaniasis (CL) is one of the most prevalent cutaneous parasitic protozoan infections in Iraq; characterized by a chronic infection and granulomatous disease that invades the skin. Type 1 immune was predominates in CL patients with exacerbated production of pro-inflammatory cytokine, therefore this study aimed to evaluate serum level of ...
Reem Aladdin Jameel, B. N. Al-Qadhi
openaire   +2 more sources

Bacillus alcalophiluspeptidoglycan induces IFN-α-mediated inhibition of vaccinia virus replication [PDF]

FEMS Immunology & Medical Microbiology, 2004
Bacterial products such as cell walls (CW) and peptidoglycan (PGN) are known to activate macrophages and NK cells during microbial infections. In this report, we demonstrated that whole CW and PGN of four Gram-positive bacteria are capable of enhancing the anti-poxviral activity of murine macrophage RAW 264.7 cells.
Ge, Liu, Qingzhu, Zhai, Dustin, Schaffner, Taissia, Popova, Alice, Hayford, Charlie, Bailey, Ken, Alibek   +6 more
openaire   +2 more sources

Human cytomegalovirus UL23 inhibits transcription of interferon-γ stimulated genes and blocks antiviral interferon-γ responses by interacting with human N-myc interactor protein. [PDF]

PLoS Pathogens, 2018
Interferon-γ (IFN-γ) represents one of the most important innate immunity responses in a host to combat infections of many human viruses including human herpesviruses.
Linyuan Feng, Jingxue Sheng, Gia-Phong Vu, Yujun Liu, Chingman Foo, Songbin Wu, Phong Trang, Marco Paliza-Carre, Yanhong Ran, Xiaoping Yang, Xu Sun, Zemin Deng, Tianhong Zhou, Sangwei Lu, Hongjian Li, Fenyong Liu   +15 more
doaj   +1 more source

Effects of Interferon-Gamma 1-b (IFN-γ) on Neutrophil Function and Biochemistry in Patients with Chronic Granulomatous Disease

Blood, 2018
Abstract Introduction: Chronic Granulomatous Disease (CGD) is a genetic disorder of the Nox2 enzyme system in phagocytic cells. Neutrophils and monocytes from patients with CGD are deficient in Nox2 components, unable to produce superoxide anion and other reactive oxygen species (ROS), and cannot kill certain types of bacteria and fungi.
Daniel R. Ambruso, Michael Ellison, Natalie Briones, Alexander Tran   +3 more
openaire   +1 more source

IFN-γ differentially modulates memory-related processes under basal and chronic stressor conditions [PDF]

Frontiers in Cellular Neuroscience, 2014
Cytokines are inflammatory messengers that orchestrate the brain's response to immunological challenges, as well as possibly even toxic and psychological insults. We previously reported that genetic ablation of the pro-inflammatory cytokine, interferon-gamma (IFN-γ), attenuated some of the corticosteroid, cytokine, and limbic dopaminergic variations ...
Litteljohn, Darcy, Nelson, Eric, Hayley, Shawn   +2 more
openaire   +3 more sources

Reciprocal interaction between macrophages and T cells stimulates IFN-γ and MCP-1 production in Ang II-induced cardiac inflammation and fibrosis. [PDF]

PLoS ONE, 2012
BACKGROUND: The inflammatory response plays a critical role in hypertension-induced cardiac remodeling. We aimed to study how interaction among inflammatory cells causes inflammatory responses in the process of hypertensive cardiac fibrosis.
Ya-lei Han, Yu-lin Li, Li-xin Jia, Ji-zhong Cheng, Yong-fen Qi, Hong-jia Zhang, Jie Du   +6 more
doaj   +1 more source

INTERLEUKIN -2 ( IL-2 ) AND GAMMA INTERFERON ( IFN γ ) OF LYMPHOCYTE CULTURE SUPERNATANT IN IRON DEFICIENCY ANEMIA PATIENTS WITH INFECTION

Indonesia Journal of Biomedical Science, 2012
Iron is an essential nutrient for every living cells because of it role as molecule fortransport of oxygen, as well as DNA synthesis through synthesis of ribonucleotidereductase. Iron deficiency anemia patients, especially pregnant women and children aremore susceptible to infection because of deterioration of their immune response.
Ketut Suega, I M Bakta, AAG Sudewa D., Ketut Suata   +3 more
openaire   +1 more source

Host immune responses after hypoxic reactivation of IFN-γ induced persistent Chlamydia trachomatis infection [PDF]

Frontiers in Cellular and Infection Microbiology, 2014
Genital tract infections with Chlamydia trachomatis (C. trachomatis) are the most frequent sexually transmitted disease worldwide. Severe clinical sequelae such as pelvic inflammatory disease (PID), tubal occlusion, and tubal infertility are linked to inflammatory processes of chronically infected tissues.
Stefan eJerchel, Inga eKaufhold, Larissa eSchuchardt, Kensuke eShima, Jan eRupp, Jan eRupp   +5 more
openaire   +3 more sources

Differential Early Secreted Antigen Target (ESAT) 6 kDa–induced IFN-γ and SOCS1 expression distinguishes latent and active tuberculosis

Journal of Infection in Developing Countries, 2014
Introduction: Expression of Suppressor of cytokine signaling (SOCS)-1 molecules is increased in patients with tuberculosis (TB). Early Secreted Antigen Target (ESAT)-6 kDa – induced IFN-γ responses indicate Mycobacterium tuberculosis infection.
Kiran Iqbal Masood, Rabia Hussain, Nisar Rao, Martin E Rottenberg, Naseem Salahuddin, Muhammad Irfan, Zahra Hasan   +6 more
doaj   +1 more source