Results 41 to 50 of about 304,612 (248)

WITHDRAWN: IFN-γ and IL-1β treated-human placenta-derived mesenchymal stromal cells enhance the generation of IL-10+T cells by upregulating PDLs expressions and ameliorate experimental autoimmune encephalomyelitis

Oncotarget, 2018
// Zhuoya Wang 1, * , Weiwei Wang 1, * , Yun Hou 2 , Aiping Zhang 1 , Guoyan Wang 3 , Junzhu Yi 1 , Qiang Fu 1 and Xiying Luan 1, 4 1 Department of Immunology, Binzhou Medical University, Shandong Province, Yantai 264003, People’s Republic of China 2 Department of Histology and Embryology, Binzhou Medical University, Shandong Province ...
Zhuoya Wang, Zhuoya Wang, Weiwei Wang, Weiwei Wang, Yun Hou, Yun Hou, Aiping Zhang, Aiping Zhang, Guoyan Wang, Guoyan Wang, Junzhu Yi, Junzhu Yi, Qiang Fu, Qiang Fu, Xiying Luan, Xiying Luan   +15 more
openaire   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Pinealectomy alters IFN-γ and IL-10 levels in primary thymocyte culture of rats

Cellular and Molecular Biology, 2018
Melatonin, produced mainly by the pineal gland, has an immunomodulatory role. However, the effects of the pineal gland and/or melatonin on thymus cytokine levels such as interferon-gamma (IFN-γ), interleukin (IL)-4, and IL-10 are not well known. Twenty-one male Wistar rats (220-250 gr) were randomly divided into three groups (n=7): intact control ...
Zafer Sahin, Suleyman Sandal, Bayram Yilmaz, Ozgur Bulmus, Gokcen Ozdemir, Selim Kutlu, Ahmet Godekmerdan, Haluk Kelestimur   +7 more
openaire   +4 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Effect of Immunization of The Pili Protein 65.5 kDa Klebsiella pneumoniae on IFN-γ Levels of Spleen BALB/c Mice

Indonesian Journal of Tropical and Infectious Disease
Klebsiella pneumoniae is a Gram-negative bacterium that poses a threat to the global community. Currently, no vaccine for K. pneumoniae is licensed by the Food and Drug Administration (FDA). The delay in the manufacture of the K. pneumoniae vaccine was because many vaccine candidates failed at the clinical trial stage due to adverse cross-reactions ...
Ajeng Samrotu Sa'adah, Diana Chusna Mufida, null Dini Agustina, null Pulong Wijang Pralampita   +3 more
openaire   +1 more source

MOESM1 of The combination of Radix Astragali and Radix Angelicae Sinensis attenuates the IFN-γ-induced immune destruction of hematopoiesis in bone marrow cells

, 2019
Additional file 1 Inspection reports of Radix Astragali and Radix Angelicae Sinensis.
Liu, Juan, Wei, Jie, Wang, Changzhi, Meng, Xiaoying, Chen, Hening, Deng, Peiying, Huandike, Meiyier, Zhang, Huijie, Li, Xue, Chai, Limin   +9 more
openaire   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Blockade Effects of Anti-Interferon- (IFN-) γ Autoantibodies on IFN-γ-Regulated Antimicrobial Immunity

Journal of Immunology Research, 2019
The interferon- (IFN-) γ expression is elicited in response to microbial infections and activates immune surveillance by antimicrobial immune elements to induce microbial killing.
Dyah Ika Krisnawati, Yung-Ching Liu, Yuarn-Jang Lee, Yun-Ting Wang, Chia-Ling Chen, Po-Chun Tseng, Ting-Jing Shen, Chiou-Feng Lin   +7 more
doaj   +1 more source

IFN-γ, should not be ignored in SLE

Frontiers in Immunology, 2022
Systemic lupus erythematosus (SLE) is a typical autoimmune disease with a complex pathogenesis and genetic predisposition. With continued understanding of this disease, it was found that SLE is related to the interferon gene signature.
Wenping Liu, Shumin Zhang, Jibo Wang
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source