Results 71 to 80 of about 236,190 (268)

Topics on the Na+/Ca2+ Exchanger: Responses of Na+/Ca2+ Exchanger to Interferon-γ and Nitric Oxide in Cultured Microglia

Journal of Pharmacological Sciences, 2006
The Na+/Ca2+ exchanger (NCX) plays a role in regulation of intracellular Ca2+ levels, but little is known about the functional role of NCX in microglia.
Toshio Matsuda, Takayuki Nagano, Motohiko Takemura, Akemichi Baba   +3 more
doaj   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Additional file 6: Table S2. of Integrative modelling of TIR domain-containing adaptor molecule inducing interferon-β (TRIF) provides insights into its autoinhibited state

, 2017
Summary of interface residues identified in the different models generated by semi-guided docking using the Cluspro docking program. (DOCX 13Â kb)
Mahita, Jarjapu, Sowdhamini, Ramanathan
openaire   +1 more source

Stromal‐Derived IL‐8 Promotes M2 Macrophage Polarization via the RhoA/MRTF‐A/SRF Transcriptional Axis to Impair CD8+ T Cell Cytotoxicity in Lung Cancer

Advanced Science, EarlyView.
In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Xuyu Gu, Qiyu Fang, Jia Yu, Ting Yu, Huashan Shi, Kaiqi Jin, Lei Jiang, Wentian Zhang   +7 more
wiley   +1 more source

Curcumin and Omega-3 Fatty Acids Enhance NK Cell-Induced Apoptosis of Pancreatic Cancer Cells but Curcumin Inhibits Interferon-γ Production: Benefits of Omega-3 with Curcumin against Cancer

Molecules, 2015
STAT-3 and STAT-1 signaling have opposite effects in oncogenesis with STAT-3 acting as an oncogene and STAT-1 exerting anti-oncogenic activities through interferon-γ and interferon-α. The cytokine IL-6 promotes oncogenesis by stimulation of NFκB and STAT-
Milan Fiala
doaj   +1 more source

Additional file 1: of Integrative modelling of TIR domain-containing adaptor molecule inducing interferon-β (TRIF) provides insights into its autoinhibited state

, 2017
Appendix S1. List of organisms used for co-evolution analysis (DOCX 16 kb)
Jarjapu Mahita, Sowdhamini, Ramanathan
openaire   +1 more source

Additional file 1: of Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial

, 2018
SPIRIT 2013 Checklist: recommended items to address in a clinical trial protocol and related documents*. (DOC 120 kb)
Arabi, Yaseen, Alothman, Adel, Balkhy, Hanan, Al-Dawood, Abdulaziz, AlJohani, Sameera, Al Harbi, Shmeylan, Kojan, Suleiman, Al Jeraisy, Majed, Deeb, Ahmad, Assiri, Abdullah, Al-Hameed, Fahad, AlSaedi, Asim, Mandourah, Yasser, Almekhlafi, Ghaleb, Sherbeeni, Nisreen, Elzein, Fatehi, Memon, Javed, Taha, Yusri, Almotairi, Abdullah, Maghrabi, Khalid, Qushmaq, Ismael, Al Bshabshe, Ali, Kharaba, Ayman, Shalhoub, Sarah, Jose, Jesna, Fowler, Robert, Hayden, Frederick, Hussein, Mohamed   +27 more
openaire   +1 more source

A 3D Human Bone and Bone Marrow‐on‐a‐Chip Model for In Vitro Bone Remodeling and Immune Cell Maintenance

Advanced Science, EarlyView.
This study presents a human Bone (and Bone Marrow)‐on‐a‐Chip model based on native human bone scaffolds and autologous cells. Dynamic perfusion and sequential cell seeding replicate the physiological bone remodeling process in vitro, enabling the long‐term culture of functional, mature bone marrow immune subpopulations.
Nina Stelzer, Melanie‐Jasmin Ort, Kristian Händler, Emely Bortel, Ioanna Maria Dimitriou, Martin Textor, Georg N. Duda, Janosch Schoon, Uwe Marx, Uwe Kornak, Annika Winter, Bernhard Hesse, Stefanie Donner, Sebastian Hardt, Oliver Klein, Simon Reinke, Malte Spielmann, Sven Geißler   +17 more
wiley   +1 more source

Cytokine Production by Human Colonic Intraepithelial Lymphocytes in Controls and Ulcerative Colitis

Mediators of Inflammation, 1994
Using an ELISA technique, concentrations of γ-interferon and interleukin-2 were assayed in the supernatants of colonic intraepithelial lymphocytes cultured with or without phytohaemagglutinin (PHA).
P. Hoang, H. R. Dalton, H. J. de Silv, D. P. Jewell   +3 more
doaj   +1 more source

Additional file 2: Figure S1. of Integrative modelling of TIR domain-containing adaptor molecule inducing interferon-β (TRIF) provides insights into its autoinhibited state

, 2017
The concatenated multiple sequence alignment of the N-terminal domain and TIR domain sequences from different organisms used for predicting co-evolving pair of residues. The region of the MSA corresponding to the N-terminal domain sequences is highlighted in purple while the region corresponding to the TIR domain is highlighted in green.
Mahita, Jarjapu, Sowdhamini, Ramanathan
openaire   +1 more source