Results 11 to 20 of about 906,170 (290)

Effect of a genetically engineered interferon-alpha versus traditional interferon-alpha in the treatment of moderate-to-severe COVID-19: a randomised clinical trial

open access: yesAnnals of Medicine, 2021
Background There are few effective therapies for coronavirus disease 2019 (COVID-19) upon the outbreak of the pandemic. To compare the effectiveness of a novel genetically engineered recombinant super-compound interferon (rSIFN-co) with traditional ...
Chuan Li   +26 more
doaj   +3 more sources

CD8+ Lymphocytes from Healthy Blood Donors Secrete Antiviral Levels of Interferon-Alpha

open access: yesViruses, 2023
The adaptive immune response to viral infections features the antigen-driven expansion of CD8+ T cells. These cells are widely recognized for their cytolytic activity that is mediated through the secretion of cytokines such as perforin and granzymes ...
Fernando Teque   +3 more
doaj   +1 more source

Unilateral retinopathy post perilesional interferon α2b injections for ocular surface squamous cell carcinoma

open access: yesAmerican Journal of Ophthalmology Case Reports, 2021
Purpose: To describe the clinical course of a patient presenting with unilateral retinopathy after perilesional interferon alpha injections for treatment of ocular surface squamous cell carcinoma.
Shiv Dalla   +4 more
doaj   +1 more source

Production and Characterization of Polyclonal Antibodies Against Interferon Alpha in Mice

open access: yesBioscientific Review, 2021
The polyclonal antibodies are used extensively for research purposes in many areas of biology, such as immunoprecipitation, histochemistry, enzyme linked immunosorbent assays (ELISA), diagnosis of disease and western blots. Typically, an animal’s immune
Mehreen Fatima   +2 more
doaj   +1 more source

Interferon alpha-induced reduction in the values of myeloid-derived suppressor cells in melanoma patients [PDF]

open access: yesVojnosanitetski Pregled, 2015
Background/Aim. Interaction between tumor cells and host’s immunoregulatory cells in creation of microenvironment that supports tumor progression is the focus of numerous investigations in recent years.
Stanojević Ivan   +11 more
doaj   +1 more source

Schwannoma response to interferon alpha

open access: yesInterdisciplinary Neurosurgery, 2017
While cranial nerve schwannomas are typically benign, slow growing tumors, they are associated with morbidity both from the neuropathies and neuralgias they can produce, as well as from the treatments used to address these tumors, typically surgery or ...
Jennifer Novak   +2 more
doaj   +1 more source

Interferons in Traumatic Brain and Spinal Cord Injury: Current Evidence for Translational Application

open access: yesFrontiers in Neurology, 2018
This review article provides a general perspective of the experimental and clinical work surrounding the role of type-I, type-II, and type-III interferons (IFNs) in the pathophysiology of brain and spinal cord injury. Since IFNs are themselves well-known
Francesco Roselli   +4 more
doaj   +1 more source

Pegylated interferon-alpha-2a for the treatment of ocular surface squamous neoplasia

open access: yesOman Journal of Ophthalmology, 2022
Ocular surface squamous neoplasia (OSSN) is the most common nonpigmented ocular surface neoplasm. Interferon-alpha (IFNα)-2b has been proved to be an effective immunotherapeutic agent to treat OSSN.
Murtuza Nuruddin   +2 more
doaj   +1 more source

Transcriptional responses of tumor cell lines to interferon-alpha [PDF]

open access: yes, 2013
Interferon is an antiviral and antiproliferative cytokine therapeutically applied to treat hepatitis infection and cancer expansion. The beneficial effects of interferon-alpha are dependent on efficient signaling by activation of defined JAK-STAT pathway
Siegrist, Fredy
core   +1 more source

Retreatment with interferon-alpha and ribavirin in primary interferon-alpha non-responders with chronic hepatitis C [PDF]

open access: yes, 2000
Background/Aims: Combination therapy with interferon-alpha (IFN-alpha) plus ribavirin is more efficacious than IFN-alpha monotherapy in previously untreated patients with chronic hepatitis C and patients with IFN-alpha relapse.
Leifeld, Ludger   +8 more
core   +1 more source

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