Results 61 to 70 of about 1,154,067 (288)
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Детские инфекции (Москва), 2015 The article demonstrates that the basis for pathogenesis of acute respiratory infection (ARI ) is a deficiency in a number of factors of virus protection.
V. V. Malinovskaya +3 more
doaj +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Enhanced anti-HCV activity of interferon alpha 17 subtype
Virology Journal, 2009 Background Pegylated interferon alpha 2 (a or b) plus ribavirin is the most effective treatment of chronic hepatitis C but a large proportion of patients do not respond to therapy. So, it is interesting to improve the treatment efficacy. Interferon alpha
Dubuisson Jean +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Interferon, virus vaccines and antiviral drugs [PDF]
, 2008 The emergence of viruses with zoonotic potential, i.e. with the potential ability to cross species barriers to infect unnatural hosts, poses a huge threat to humans.
Rodrigues, Ana Mara Lopes
core +2 more sources
Th1 and Th2 cytokines are elevated in HCV-infected SVR(-) patients treated with interferon-alpha [PDF]
, 2010 [[abstract]]Interferon-alpha-based treatment is a standard therapy to cure hepatitis C virus-infected patients. However, the reasons for the failure of interferon-alpha treatment in some patients have not been fully elucidated.
Wan, L (Wan, Lei); Kung, YJ (Kung, Yung-Jen); Lin, YJ (Lin, Ying-Ju); Liao, CC (Liao, Chiu-Chu); Sheu, JJC (Sheu, Jim J. C.); Tsai, YS (Tsai, Yuhsin); Lai, HC (Lai, Hsueh-Chou); Peng, CY (Peng, Cheng-Yuan); Tsai, FJ (Tsai, Fuu-Jen)
core
, 2021 Interferon-alpha exerts proinflammatory properties in experimental radiation-induced esophagitis: possible involvement of plasmacytoid dendritic ...
Tetsuya Tanigawa (5776862)
core +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source