Results 61 to 70 of about 1,712,671 (325)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Some biological properties of the human amniotic membrane interferon

Memorias do Instituto Oswaldo Cruz, 1992
Human amniotic interferon was investigated to define the species specificity of its antiviral action and compare its anti-cellular and NK cell stimulating activities with those of other human interferons.
P. C. P. Ferreira, L. de la Roque, V. M. Rumjanek, R. R. Golgher   +3 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Experience with pegylated interferon α-2a in advanced myeloproliferative neoplasms in an international cohort of 118 patients

Haematologica, 2012
The Philadelphia negative myeloproliferative neoplasms, including polycythemia vera, essential thrombocythemia, and myelofibrosis, are associated with substantial vascular and transformative complications.
Krisstina Gowin, Prakash Thapaliya, Jan Samuelson, Claire Harrison, Deepti Radia, Bjorn Andreasson, John Mascarenhas, Alessandro Rambaldi, Tiziano Barbui, Catherine J. Rea, John Camoriano, Amy Gentry, Jean-Jacques Kiladjian, Casey O'Connell, Ruben Mesa   +14 more
doaj   +1 more source

Effect of a genetically engineered interferon-alpha versus traditional interferon-alpha in the treatment of moderate-to-severe COVID-19: a randomised clinical trial

Annals of Medicine, 2021
Background There are few effective therapies for coronavirus disease 2019 (COVID-19) upon the outbreak of the pandemic. To compare the effectiveness of a novel genetically engineered recombinant super-compound interferon (rSIFN-co) with traditional ...
Chuan Li, Fengming Luo, Chengwu Liu, Nian Xiong, Zhihua Xu, Wei Zhang, Ming Yang, Ye Wang, Dan Liu, Chao Yu, Jia Zeng, Li Zhang, Duo Li, Yanbin Liu, Mei Feng, Ruoyang Liu, Jiandong Mei, Senyi Deng, Zhen Zeng, Yuanhong He, Haiyan Liu, Zhengyu Shi, Meng Duan, Deying Kang, Jiayu Liao, Weimin Li, Lunxu Liu   +26 more
doaj   +1 more source

Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways [PDF]

, 2012
It is of considerable translational importance whether depression is a form or a consequence of sickness behavior. Sickness behavior is a behavioral complex induced by infections and immune trauma and mediated by pro-inflammatory cytokines.
A Bosutti, A Jellema, A Laugeray, A Peters, A Rossi-George, A Schaffner, AA Wadee, AH Swiergiel, AJ Grossberg, AL Hassett, AL Lacerda, AM Myint, AN van den Pol, AS El-Radhi, AS Wrynn, AY Lai, B Leonard, B Owe-Larsson, BE Leonard, BE Leonard, BG Charlton, BL Hart, Brian Leonard, C Celik, C Nathan, C Song, C Song, C Song, C Song, C Song, CA Stockmeier, Cai Song, CL Raison, D Brustolim, D Wang, DK Kinney, EA Stone, ES Wohleb, F Frenois, F Kapczinski, F Moroni, G Anderson, G Werner-Felmayer, George Anderson, GM MacQueen, GR Steinberg, H Anisman, H Anisman, H Nakanishi, HC Liu, HP Kopp, I Kirsch, IK Lampe, IR Bell, J Hannestad, J Steiner, JC O'Connor, JE Bower, JE Holmes, JL Rausch, JM Twenge, KJ Jung, KJ Tracey, KS Kendler, L MacDonald, L Qin, L Toker, LE Goehler, LE Goehler, Lisa Goehler, LJ Williams, LM Harden, LV Kessing, LV Kessing, M Adib-Conquy, M Berk, M Berk, M Berk, M Berk, M Catena-Dell'Osso, M Kauer-Sant'Anna, M Koenigs, M Kubera, M Kubera, M Lyte, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, M Maes, MB Hennessy, MB Howren, MC McKinnon, MC Wichers, MC Wichers, MC Wichers, MD Burton, ME Sublette, Michael Berk, Michael Maes, MJ Hoes, MJ Kluger, MJ Kluger, MJ Sharman, MP Szuba, MT Berlim, N Castanon, N Castex, NA Harrison, O Caliyurt, O Takikawa, P Gorwood, P Taepavarapruk, P Videbech, Piotr Gałecki, R Dantzer, R Medzhitov, R Roubenoff, R Yirmiya, RC Bone, RH Straub, RJ Boland, RK Jewkes, RK Kumar, RM Post, RPA Gaykema, RPA Gaykema, RPA Gaykema, RW Johnson, S Bonaccorso, S Bonaccorso, S Cunningham-Rundles, S Lacosta, S Rantala, S-M Park, SC Strijdom, SD Burdette, SE Møller, SF Maier, SM Antelman, SM Jancsár, SM O'Brien, SM Sylvén, T Hochstrasser, T Liukkonen, T Sato, T Tuma, TA Lennie, TC Olde Hartman, TM Piser, V Gabbay, WC Drevets, WS Yang, Y Dowlati, Y Huang, Y Jiang, Y Kawasaki, Y Liu, Z Pavlovićc, Z Xia   +189 more
core   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Effect of interferon-alpha on experimental septal fibrosis of the liver - study with a new model

Memorias do Instituto Oswaldo Cruz, 2001
Interferon-alpha is used in antiviral therapy in humans, mainly for viral hepatitis B and C. An anti-fibrotic effect of interferon has been postulated even in the absence of anti-viral response, which suggests that interferon directly inhibits ...
Marcia Maria de Souza, Raymundo Paraná, Christian Trepo, Aryon A Barbosa Jr, Irismar Oliveira, Zilton A Andrade   +5 more
doaj   +1 more source

Eccrine porocarcinoma of the head: An important differential diagnosis in the elderly patient [PDF]

, 2008
Background: Eccrine porocarcinoma is a rare malignant tumor of the sweat gland, characterized by a broad spectrum of clinicopathologic presentations. Surprisingly, unlike its benign counterpart eccrine poroma, eccrine porocarcinoma is seldom found in ...
Akiyoshi E, Brenn T, Cho SB, Daniela Bruch-Gerharz, Dummer R, Goel R, Grimme H, Gunhan, Gutermuth J, Helmke B, Klaus-Werner Schulte, Lan CC, Matloub HS, Mishima Y, Perna C, Peter Arne Gerber, Pinkus H, Plunkett TA, Puttick L, Ritter AM, Robson A, Shaw M, Sigal R, Thomas Ruzicka, Valverde K, Wittenberg GP   +25 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source