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Interferon-Gamma Release Assays
Clinics in Laboratory Medicine, 2014Diagnosis of latent tuberculosis infection (LTBI) should be targeted toward individuals and groups with high risk of progression to active tuberculosis (TB). Low-risk populations should not be screened. Interferon-gamma release assays (IGRAs) perform as well or better than the tuberculin skin test in most targeted populations.
Robert, Belknap, Charles L, Daley
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Interferon-Gamma and Polymorphonuclear Leukocytes
Annals of Internal Medicine, 1988Excerpt To the editor:In his excellent review article on interferon-gamma, Murray (1) scrupulously avoids mentioning the controversial problem of the interaction between this lymphokine and polymor...
D A, Watson, D M, Musher, R J, Hamill
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Inhibition of interferon-gamma by an interferon-gamma receptor immunoadhesin.
Immunology, 1993Interferon-gamma (IFN-gamma) is an important cytokine which regulates inflammatory and immune response mechanisms. IFN-gamma enhances the presentation and recognition of antigens by inducing the expression of major histocompatibility complex (MHC) proteins, by activating effector T cells and mononuclear phagocytes, and by modulating immunoglobulin ...
M, Haak-Frendscho +5 more
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1995
Abstract The human IFNycDNA (GenBank accession number X13274) encodes a 143-amino-acid mature protein with a 23 residue signal sequence (Gray et al. 1982). The activity of IFNy is species specific due to the low level of homology between different species sequences.
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Abstract The human IFNycDNA (GenBank accession number X13274) encodes a 143-amino-acid mature protein with a 23 residue signal sequence (Gray et al. 1982). The activity of IFNy is species specific due to the low level of homology between different species sequences.
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Interferon-gamma-inhibitory oligodeoxynucleotides alter the conformation of interferon-gamma.
Molecular pharmacology, 1998The aptamer mechanism of action involves the direct interaction of oligonucleotide with protein and is responsible for the biological effects of many pharmacologically active oligodeoxynucleotides. In the work reported here, we have determined the effects of aptamers on the secondary, tertiary, and quaternary structures of the proteins with which they ...
V, Balasubramanian +3 more
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