Results 141 to 150 of about 98,491 (346)

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

Advanced Healthcare Materials, EarlyView.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang, Si‐Bo Yang, Yan Luo, Xiao‐Di Sun, Bo‐Hao Chang, Da‐Qiang Zhou, Jun‐Jie Jiang, Ya‐Nan Li, Jie‐Hong Wu, Hui‐Juan Jin, Hang Yang, Hang Hu, Yi‐Fan Zhou, Bo Hu   +13 more
wiley   +1 more source

Distinct cytokine patterns in Occult Hepatitis C and Chronic Hepatitis C Virus Infection [PDF]

, 2011
Background & Aim: The immunopathogenesis of chronic hepatitis C virus (HCV) infection is a matter of great controversy. The imbalance of T-helper lymphocyte cell cytokine production was believed to play an important pathogenic role in ...
Azza Azza Abdel-Aziz, Mohamed Abd-elmaksoud, Mona Elhadidy, Nashwa Abousamra, Nasser Mousa, Yahia Gad   +5 more
core   +1 more source

Systematic review and meta-analysis on the utility of Interferon-gamma release assays for the diagnosis of Mycobacterium tuberculosis infection in children: a 2013 update

BMC Infectious Diseases, 2014
BackgroundPrevious meta-analyses regarding the performance of interferon-gamma release assays (IGRAs) for tuberculosis diagnosis in children yielded contrasting results, probably due to different inclusion/exclusion criteria.MethodsWe systematically ...
S. Sollai, L. Galli, M. Martino, E. Chiappini   +3 more
semanticscholar   +1 more source

Capturing Recent Mycobacterium tuberculosis Infection by Tuberculin Skin Test vs. Interferon-Gamma Release Assay

Tropical Medicine and Infectious Disease
Reductions in tuberculosis (TB) incidence require identification of individuals at high risk of developing active disease, such as those with recent Mycobacterium tuberculosis (Mtb) infection. Using a prospective household contact (HHC) study in Kampala, Uganda, we diagnosed new Mtb infection using both the tuberculin skin test (TST) and interferon ...
Jesús Gutierrez, Mary Nsereko, LaShaunda L. Malone, Harriet Mayanja-Kizza, Hussein Kisingo, W. Henry Boom, Charles M. Bark, Catherine M. Stein   +7 more
openaire   +3 more sources

Ferritin‐Doped Nanoparticles Triggered Tumor‐Specific Darkening for Enhanced Photothermal Tumor Ablation and Immune Activation

Advanced Healthcare Materials, EarlyView.
Ferritin‐doped hybrid nanoparticles triggered accurate tumor‐specific hemorrhage for enhanced in situ photothermal therapy and evoked anti‐tumor immunity. Notably, HFn/GA‐Fe specifically induced tumor hemorrhage 12 h after intravenous injection, resulting in visible color darkening. Through photoacoustic imaging, tumor vessels could be clearly observed
Haidong Zha, Xiao Liang, Long Xi, Jiamao Chen, Wenzhao Zhong, Zhen Yuan, Meng Xu, Ying Zheng   +7 more
wiley   +1 more source

PiP‐Plex: A Particle‐in‐Particle System for Multiplexed Quantification of Proteins Secreted by Single Cells

Advanced Materials, EarlyView.
Detecting proteins secreted by a single cell while retaining its viability remains challenging. A particles‐in‐particle (PiPs) system made by co‐encapsulating barcoded microparticles (BMPs) with a single cell inside an alginate hydrogel particle is introduced.
Félix Lussier, Byeong‐Ui Moon, Mojra Janta‐Polczynski, Yonatan Morocz, Fabian Svahn, Molly Shen, Ljuboje Lukic, Lidija Malic, Teodor Veres, Andy Ng, David Juncker   +10 more
wiley   +1 more source

The Feasibility of the Interferon Gamma Release Assay and Predictors of Discordance with the Tuberculin Skin Test for the Diagnosis of Latent Tuberculosis Infection in a Remote Aboriginal Community

PLoS ONE, 2014
Background The tuberculin skin test (TST) is the standard test used to screen for latent TB infection (LTBI) in the northern Canadian territory of Nunavut. Interferon gamma release assays (IGRA) are T cell blood-based assays to diagnose LTBI.
G. Alvarez, D. V. Van Dyk, Naomi Davies, S. Aaron, D. Cameron, M. Desjardins, R. Mallick, N. Obed, M. Baikie   +8 more
semanticscholar   +1 more source

Mesenchymal Stem Cell‐Inspired Microneedle Platform for NIR‐responsive Immunomodulation and Accelerated Chronic Wound Healing

Advanced Materials, EarlyView.
The research demonstrates a Mesenchymal Stem Cell‐inspired microneedle platform (MSCi@MN) that addresses chronic diabetic wounds by combining MSC‐derived extracellular nanovesicles (NV)–DNA conjugates in microneedle tips with photothermal MXene in the patch layer.
Chan Ho Moon, Hee Gyeong Ko, Hyun Lee, Seojoon Bang, Hyeong Seok Kang, Ju Yeong Gwon, Jong Hwa Seo, Nayoung Lee, So Won Jeon, Yun‐A Kim, Jong Sang Yoon, Kyung‐Yup Cha, Min‐Ho Kang, Dong Yun Lee, Soo‐Hong Lee, Gi Doo Cha, Kisuk Yang, Donghyun Lim, Heemin Kang, Su Ryon Shin, Han Young Kim, Hyun‐Do Jung   +21 more
wiley   +1 more source

Recommendations for the diagnosis of pediatric tuberculosis [PDF]

, 2016
Tuberculosis (TB) is still the world's second most frequent cause of death due to infectious diseases after HIV infection, and this has aroused greater interest in identifying and managing exposed subjects, whether they are simply infected or have ...
A Catanzaro, A Cattamanchi, A Gwee, A Lalvani, A Mukherjee, A Naseer, A Polesky, A. Guarino, A. Lo Vecchio, A. Villani, AE Khan, AJ Hayes, AK Detjen, AM Mandalakas, American Academy of Pediatrics, American Academy of Pediatrics, American Thoracic Society, AR Bamford, AT Cruz, AT Cruz, BJ Marais, BJ Marais, BJ Marais, BJ Marais, BM Bergamini, C Debord, C Duicu, C Piersimoni, C Winston, C. Gabiano, C. Russo, Centers for Disease Control and Prevention (CDC), CLSI, CLSI, CT Hugo-Hamman, D Buonsenso, D Menzies, D Parashar, D Wang, D. Ciofi, D. Cirillo, DA Lewinsohn, DB Young, DC Stefan, DE Griffith, DE Snider Jr, DI Ling, DI Ling, E Bruzzese, E Chiappini, E Chiappini, E Tortoli, E Tortoli, E. Castagnola, E. Chiappini, E. Tortoli, EA Burkett, EC Pearce, EM Trecarichi, F Chow, F Laraque, F Tinsa, F. Bernardi, FG Youssef, G Antonucci, G Hussey, G Mazurek, G. L. Marseglia, G. Losurdo, GE Oramasionwu, GE Thwaites, HA Moore, HC Maltezou, HE Teo, HJ Zar, HS Hosalkar, I Berggren Palme, I Pavić, I Shah, I Solovic, J Cordova, JR Starke, K Okada, K Schepers, K Weyer, KK Locham, KS Wong, L Bianchi, L Cormican, L Pollock, L Pontual de, L Richeldi, L Richeldi, LE Scott, LM Franchi, M Bates, M Brown, M Hatherill, M Losi, M Pienaar, M. Bocchino, M. Tadolini, MA Davies, MB Conde, ME Török, MP Golden, MV Rose, MX Rangaka, N Principi, N Tukvadze, NJ Farinha, NS Planting, O Boachie-Adjei, O Uygur-Bayramicli, P Britton, P Hepple, P Miotto, P Miotto, P. Tomà, PA Jong de, PC Hopewell, PM Pasco, R Basu Roy, R Kumar, R Zrinski Topić, RA Leder, RG English, RN Zyl-Smit van, S Andronikou, S Andronikou, S Khalilzadeh, S Lucas, S Marais, S Moyo, S Owens, S. Esposito, S. Garazzino, SA Madhi, SC Auld, SE McMullen, T Haustein, UA Qureshi, W Phongsamart   +142 more
core   +1 more source

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source