Results 121 to 130 of about 779,562 (365)
Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response
Nature Communications, 2017 Gram-negative bacteria actively secrete outer membrane vesicles, spherical nano-meter-sized proteolipids enriched with outer membrane proteins, to the surroundings.
O. Y. Kim +7 more
semanticscholar +1 more source
Regulation of hematopoietic stem cell activity by inflammation
Frontiers in Immunology, 2013 Hematopoietic stem cells (HSCs) are quiescent cells with self-renewal capacity and the ability to generate all mature blood cells. HSCs normally reside in specialized niches in the bone marrow that help maintain their quiescence and long-term ...
Laura eSchuettpelz, Daniel eLink
doaj +1 more source
Signal propagation in sensing and reciprocating cellular systems with spatial and structural heterogeneity [PDF]
arXiv, 2018 Sensing and reciprocating cellular systems (SARs) are important for the operation of many biological systems. Production in interferon (IFN) SARs is achieved through activation of the Jak-Stat pathway, and downstream upregulation of IFN regulatory factor (IRF)-3 and IFN transcription, but the role that high and low affinity IFNs play in this process ...
arxiv
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background and Objectives Ofatumumab, a fully human anti‐CD20 monoclonal antibody, is effective in reducing relapses and disability progression in patients with multiple sclerosis. This study aimed to examine immune profile changes associated with ofatumumab in a prospective cohort of Chinese patients with relapsing–remitting multiple ...
Shu Yang +9 more
wiley +1 more source
Elevated Levels of Proinflammatory Cytokines in Cerebrospinal Fluid of Multiple Sclerosis Patients
Frontiers in Immunology, 2017 Multiple sclerosis (MS) is an autoimmune neurodegenerative disease characterized by chronic brain inflammation. Leukocyte infiltration of brain tissue causes inflammation, demyelination, and the subsequent formation of sclerotic plaques, which are a ...
Timur Khaibullin +8 more
doaj +1 more source
REP: Predicting the Time-Course of Drug Sensitivity [PDF]
arXiv, 2019 The biological processes involved in a drug's mechanisms of action are oftentimes dynamic, complex and difficult to discern. Time-course gene expression data is a rich source of information that can be used to unravel these complex processes, identify biomarkers of drug sensitivity and predict the response to a drug.
arxiv
Relation of interferon synthesis to abortive replication of Newcastle disease virus in L cells [PDF]
, 1968 Juliuss . Youngner, Anne W. Scott
openalex +1 more source
Interferon and Interferon Inducers in Protozoal Infections [PDF]
The Journal of General Physiology, 1970 Several interferon inducers (Newcastle disease virus, statolon, and poly rI:poly rC) as well as exogenous mouse interferon protect mice from sporozoite-induced Plasmodium berghei malaria, as long as they are administered before the end of the preerythrocytic phase of development of the parasite.
openaire +3 more sources
The Regulation of Trace Metal Elements in Cancer Ferroptosis
Advanced Biology, EarlyView.The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang +5 more
wiley +1 more source
Nature Communications, 2018 Although anti-tumor necrosis factor (TNF) agents are highly effective in the treatment of psoriasis, 2–5% of treated patients develop psoriasis-like skin lesions called paradoxical psoriasis.
C. Conrad +9 more
semanticscholar +1 more source