Results 101 to 110 of about 607,302 (313)

A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C [PDF]

, 2012
Background: To perform a comprehensive study on the relationship between vitamin D metabolism and the response to interferon-α-based therapy of chronic hepatitis C.
Jörg Bojunga, Raffaele Malinverni, Gerlach, Tilman J., Gerlach, Tilman J, Tilman J Gerlach, Swiss Hepatitis C Cohort Study Group,, Berg, T., Kutalik, Z., Stephanie Bibert, Christian M Lange, Geier, Andreas, Dufour, Jean-François Jacques, Thomas Berg, Malinverni, Raffaele, Regenass, S., Burgisser, Philippe, Regenass, Stephan, Badenhoop, Klaus, Bojunga, Jörg, Lange, Christian M, Dufour, J. F., Stephan Regenass, Gerlach, Tilman Joern, Swiss Hepatitis C Cohort Study Group, Bochud, P. Y., Dufour, Jean-Francois, Bojunga, J., Andreas Geier, Stefan Zeuzem, Negro, F., Cerny, A., Zoltan Kutalik, Lange, Christian, Pierre-Yves Bochud, Sarrazin, C., Tobias Müller, Sarrazin, Christoph, Lange, C. M., Cerny, Andreas, Kutalik, Zoltán, Bibert, S., Malinverni, R., Moradpour, Darius, Christoph Sarrazin, Burgisser, P., Gerlach, T. J., Moradpour, D., Bibert, Stephanie, Klaus Badenhoop, Zeuzem, S., Negro, Francesco, Müller, Tobias, Badenhoop, K., Andreas Cerny, Bochud, Pierre-Yves, Geier, A., Heim, M. H., Muller, T., Francesco Negro, Berg, Thomas, Markus H Heim, Heim, Markus H., Darius Moradpour, Jean-Francois Dufour, Philippe Burgisser, Heim, Markus H, Zeuzem, Stefan   +66 more
core   +1 more source

The IFITMs Inhibit Zika Virus Replication

Cell Reports, 2016
Zika virus has emerged as a severe health threat with a rapidly expanding range. The IFITM family of restriction factors inhibits the replication of a broad range of viruses, including the closely related flaviruses West Nile virus and dengue virus. Here,
George Savidis, Jill M. Perreira, Jocelyn M. Portmann, Paul Meraner, Zhiru Guo, Sharone Green, Abraham L. Brass   +6 more
doaj   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

The human interferon-induced MxA protein inhibits early stages of influenza A virus infection by retaining the incoming viral genome in the cytoplasm

, 2013
The induction of an interferon-induced antiviral state is a powerful cellular response against viral infection that limits viral spread. Here we show that a pre-existing antiviral state inhibits replication of influenza A viruses in human A549 cells by ...
Xiao, Han, Killip, Marian Jane, Killip, Marian J., Stäheli, Peter, Staeheli, Peter, Randall, Richard Edward, Jackson, David   +6 more
core   +1 more source

Deep sequencing analysis of defective genomes of parainfluenza virus 5 and their role in interferon induction [PDF]

, 2013
This work was supported by The Wellcome Trust (087751/A/08/Z).Preparations of parainfluenza virus 5 (PIV5) that are potent activators of the interferon (IFN) induction cascade were generated by high-multiplicity passage in order to accumulate defective ...
Killip, M. J., Davison, A. J., Young, D.F., Goodbourn, S., Ross, C.S., Young, D. F., Davison, A.J., Short, J.A.L., Ross, C. S., Randall, R. E., Gatherer, D., Short, J. A. L., Killip, M.J., Randall, R.E.   +13 more
core   +1 more source

Plasma interferon predicts pulmonary hypertension severity and outcome

Frontiers in Cardiovascular Medicine
BackgroundPulmonary hypertension (PH) is a complex and progressive disease characterized by elevated pulmonary vascular resistance. Inflammation plays an important role in the pathogenesis of PH.
Zhanping Liang, Zhanping Liang, Yun Li, Shuying Jia, Yuyan Liu, Jie Zhu, Jinling Li, Fei Li, Xiaohuan Xia, Xiaohuan Xia, Xiaohuan Xia, Xiaohuan Xia, Xiaohuan Xia, Xiaohuan Xia   +13 more
doaj   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Interferon-γ is a crucial activator of early host immune defense against Mycobacterium ulcerans infection in mice [PDF]

, 2016
Buruli ulcer (BU), caused by infection with Mycobacterium ulcerans, is a chronic necrotizing human skin disease associated with the production of the cytotoxic macrolide exotoxin mycolactone.
Miriam Bolz, Bolz, Miriam, Gerd Pluschke, Miriam Bolz (309717), Raphael Bieri (849790), Raphael Bieri, Bieri, Raphael, Marie-Thérèse Ruf, Marie-Thérèse Ruf (2280196), Gerd Pluschke (7855), Ruf, Marie-Thérèse, Pluschke, Gerd   +11 more
core   +1 more source

Interferon and immunity: the role of microRNA in viral evasion strategies

Frontiers in Immunology
Interferons (IFNs) are indispensable innate antiviral cytokines that orchestrate the vertebrate immune response against viral incursions. Nearly every cell possesses the remarkable ability to release IFNs upon detecting viral threats, triggering a robust
Mobina Bayat, Mobina Bayat, Rahil Nahid-Samiei, Javid Sadri Nahand, Javid Sadri Nahand, Behrouz Naghili   +5 more
doaj   +1 more source

Role of Type I and II Interferons in Colorectal Cancer and Melanoma

Frontiers in Immunology, 2017
Cancer can be considered an aberrant organ with a hierarchical composition of different cell populations. The tumor microenvironment, including the immune cells and related cytokines, is crucial during all the steps of tumor development.
Simone Di Franco, Alice Turdo, Matilde Todaro, Matilde Todaro, Giorgio Stassi   +4 more
doaj   +1 more source