Results 81 to 90 of about 607,302 (313)

Interferon beta-1b treatment does not induce autoantibodies

, 2005
Background: There is little information regarding the potential of interferon beta ( IFN beta) to induce or exacerbate autoimmune disease. Existing data from uncontrolled studies are contradictory and do not differentiate between autoimmune dysfunction ...
C. H. Polman, F. Dahlke, R. Graf, K. Beckmann, A. J. Thompson, POZZILLI, Carlo, European Study Group On Interferon Beta B. In Spms, L. Kappos, T. Bogumil   +8 more
core   +1 more source

The producer cell type of HSV-1 alters the proteomic contents and infectious capacity of virions

Journal of Virology
The cell that a virus replicates in, that is, the producer cell, can alter the macromolecular composition and infectious capacity of the virions that are produced.
Gary Dunn, Luke F. Domanico, Matthew P. Taylor   +2 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Effect of interferon-alpha on progression of cirrhosis to hepatocellular carcinoma: a retrospective cohort study.

, 1998
BACKGROUND: There is debate about whether interferon-alpha treatment lowers the risk of progression to hepatocellular carcinoma in patients with chronic viral hepatitis and cirrhosis and whether any effect is limited to certain subgroups. We investigated
(INTERNATIONAL HEPATOCELLULAR CARCINOMA STUDY GROUP, BENVEGNU', LUISA, INTERNATIONAL INTERFERON ALPHA HEPATOCELLULAR CARCINOMA STUDY GROUP, BONINO, FERRUCCIO   +3 more
core  

Treatment options in non-muscle-invasive bladder cancer after BCG failure

Indian Journal of Urology, 2015
Bladder cancer is the ninth-most prevalent cancer worldwide. Most patients with urothelial cell carcinoma of the bladder present with non-muscle-invasive disease and are treated with bacillus Calmette-Guérin (BCG) intravesical therapy.
Nathan A Brooks, Michael A O'Donnell
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis

Frontiers in Immunology, 2019
Viral encephalitis is a rare but clinically serious consequence of viral invasion of the brain and insight into its pathogenesis is urgently needed. Important research questions concern the involvement of the host innate immune response in pathogenesis ...
Catherine F. Hatton, Christopher J. A. Duncan, Christopher J. A. Duncan   +2 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Low-dose endosulfan inhibits proliferation and induces senescence and pro-inflammatory cytokine production in human lymphocytes, preferentially impacting cytotoxic cells

Journal of Immunotoxicology, 2019
Endosulfan is a DDT-era organochlorine pesticide. Due to past and current environmental contamination, investigation of endosulfan exposure is of current importance. Acute high dose exposure precipitates neural/endocrine system damage, but the effects on
Martha Cecilia Téllez-Bañuelos, Salvador González-Ochoa, Pablo Cesar Ortiz-Lazareno, Vida Celeste Rosas-Gonzalez, Jaime Gómez-Villela, Jesse Haramati   +5 more
doaj   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source