Results 81 to 90 of about 675,714 (307)

Suppression of mRNA Nanoparticle Transfection in Human Fibroblasts by Selected Interferon Inhibiting Small Molecule Compounds

Biomolecules, 2017
In vitro transcribed (IVT) mRNA is increasingly applied in lieu of DNA to deliver reprogramming genes to fibroblasts for stem cell derivation. However, IVT mRNA induces interferon (IFN) responses from mammalian cells that reduces transfection efficiency.
Yang Liu, Manoj N. Krishnan, Kyle K.L. Phua   +2 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Interferon-γ is a crucial activator of early host immune defense against Mycobacterium ulcerans infection in mice [PDF]

, 2016
Buruli ulcer (BU), caused by infection with Mycobacterium ulcerans, is a chronic necrotizing human skin disease associated with the production of the cytotoxic macrolide exotoxin mycolactone.
Miriam Bolz, Bolz, Miriam, Gerd Pluschke, Miriam Bolz (309717), Raphael Bieri (849790), Raphael Bieri, Bieri, Raphael, Marie-Thérèse Ruf, Marie-Thérèse Ruf (2280196), Gerd Pluschke (7855), Ruf, Marie-Thérèse, Pluschke, Gerd, Pluschke G, Bolz M, Ruf MT, Bieri R   +15 more
core   +2 more sources

Impaired activation of plasmacytoid dendritic cells via toll-like receptor 7/9 and STING is mediated by melanoma-derived immunosuppressive cytokines and metabolic drift

Frontiers in Immunology
IntroductionPlasmacytoid dendritic cells (pDCs) infiltrate a large set of human cancers. Interferon alpha (IFN-α) produced by pDCs induces growth arrest and apoptosis in tumor cells and modulates innate and adaptive immune cells involved in anti-cancer ...
Matilde Monti, Giorgia Ferrari, Valentina Grosso, Francesco Missale, Francesco Missale, Mattia Bugatti, Valeria Cancila, Stefania Zini, Agnese Segala, Luca La Via, Francesca Consoli, Matteo Orlandi, Alessandra Valerio, Claudio Tripodo, Claudio Tripodo, Marzia Rossato, William Vermi, William Vermi   +17 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Aromatic amino acid metabolites alter interferon signaling and influenza pathogenesis

Frontiers in Molecular Biosciences
The ability of gut microbial metabolites to influence the host is increasingly recognized. The microbiota extensively metabolizes the three aromatic amino acids, tryptophan, tyrosine, and phenylalanine.
Gautam Anand, Colin Clark-Dinovo, Alexandra M. Perry, Victoria M. Goodwin, Emma St. Raymond, Sonia Sakleshpur, Ashley L. Steed   +6 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Effect of interferon-alpha on progression of cirrhosis to hepatocellular carcinoma: a retrospective cohort study.

, 1998
BACKGROUND: There is debate about whether interferon-alpha treatment lowers the risk of progression to hepatocellular carcinoma in patients with chronic viral hepatitis and cirrhosis and whether any effect is limited to certain subgroups. We investigated
(INTERNATIONAL HEPATOCELLULAR CARCINOMA STUDY GROUP, BENVEGNU', LUISA, INTERNATIONAL INTERFERON ALPHA HEPATOCELLULAR CARCINOMA STUDY GROUP, BONINO, FERRUCCIO   +3 more
core  

Herpes simplex virus triggers and then disarms a host antiviral response [PDF]

, 2001
Virus infection induces an antiviral response that is predominantly associated with the synthesis and secretion of soluble interferon. Here, we report that herpes simplex virus type 1 virions induce an interferon-independent antiviral state in human ...
Smiley, J R, Macgregor, P F, Edwards, A M, Mossman, K L, Rozmus, J J, Goryachev, A B   +5 more
core   +1 more source

Pathophysiology and stratification of treatment-resistant rheumatoid arthritis

Immunological Medicine
Early diagnosis and timely therapeutic intervention are clinical challenges of rheumatoid arthritis (RA), especially for treatment-resistant or difficult-to-treat patients. Little is known about the immunological mechanisms involved in refractory RA.
Saeko Yamada, Yasuo Nagafuchi, Keishi Fujio   +2 more
doaj   +1 more source