Results 211 to 220 of about 527,002 (316)

Neuronal C/EBPβ Shortens the Lifespan via Inactivating NAMPT

Advanced Science, EarlyView.
Schematic diagram illustrating the mechanism of shortened lifespan in Thy 1‐C/EBPβ transgenic mice and intervention strategies. Briefly, C/EBPβ/AEP escalation in the aging brain triggers NAMPT fragmentation and NAD+ depletion. Knockout of AEP from Thy 1‐C/EBPβ Tg/Tg mice ameliorates cognitive impairments and elongates the lifespan.
Bowei Li, Zhongyun Xie, Mengmeng Wang, Shuke Nie, Zhengjiang Qian, Xin Meng, Xia Liu, Seong Su Kang, Keqiang Ye   +8 more
wiley   +1 more source

cGAS/STING signalling in macrophages aggravates obliterative bronchiolitis via an IFN-α-dependent mechanism after orthotopic tracheal transplantation in mice. [PDF]

Clin Transl Med
Wan J, Liu H, Wu C, Zhou T, Yang F, Xiao X, Tong S, Wang S.   +7 more
europepmc   +1 more source

Interferon induction with statolon in the intact animal. [PDF]

, 1967
W. J. Kleinschmidt, E B Murphy
openalex   +1 more source

Reshape the Fates of Treg and CD8+T Cells Through IL‐2Rα by Synergizing Divergent Receptor‐Biased IL‐2 PEGylates

Advanced Science, EarlyView.
This study presents receptor‐biased IL‐2 PEGylates that selectively modulate IL‐2 receptor subunit interactions to enhance CD8⁺ T cell antitumor activity while curbing Treg activation and endothelial toxicity. The combined not‐α and not‐β variants balance immune stimulation and prevent T cell exhaustion, offering a novel, fine‐tuned approach for ...
Jiaqi Sun, Lingfeng Guo, Dezhong Ji, Mengfan Yu, Boyang Cheng, Xingxing Zhu, Yeshuang Yuan, Siyu Wu, Yuanjie Zhang, Wen Shi, Zhiqian Chen, Xindang Chu, Jiayu Hu, Liwen Hua, Yiming Wang, Yanning Zhu, Yu Mu, Hanwen Sun, Chuanling Zhang, Qi Wang, Sulong Xiao, Lihe Zhang, Bo Zhang, Demin Zhou   +23 more
wiley   +1 more source

Deletion of the Human Cytomegalovirus US2 to US11 Gene Family Members Impairs the Type-I Interferon Response. [PDF]

Viruses
Penner I, Krämer N, Hirsch J, Büscher N, Schmidt H, Plachter B.   +5 more
europepmc   +1 more source

The Role of Interferon in Persistent Infection with Foot-and-Mouth Disease Virus

, 1963
Lennart Philipson, Z. Dinter
openalex   +1 more source

Transcriptome Landscape of Cancer‐Associated Fibroblasts in Human PDAC

Advanced Science, EarlyView.
AP‐1 family members FOS and JUN regulate the malignant phenotype conversion of normal fibroblasts (NFs) to normal‐like cancer‐associated fibroblasts (nCAFs), while transforming growth factor‐β (TGFβ) and interferon‐γ (IFNγ) signals triggers the interconversion between classic myofibroblastic CAFs (myCAFs) and inflammatory CAFs (iCAFs), respectively ...
Mengyu Tao, Wenting Liu, Jianhua Chen, Rujiao Liu, Jianling Zou, Bo Yu, Chenchen Wang, Mingzhu Huang, Qingjian Chen, Zhe Zhang, Zhiyu Chen, Haoyu Sun, Cheng Zhou, Shuguang Tan, Yuxuan Zheng, Hongxia Wang   +15 more
wiley   +1 more source

Tofacitinib treatment for psoriatic skin lesions associated with Aicardi-Goutières syndrome 7/Singleton-Merten syndrome 1. [PDF]

Orphanet J Rare Dis
Beerepoot S, Grinwis L, Vanderver AL, van der Knaap MS, Kuijpers TW.   +4 more
europepmc   +1 more source

Quantitative Assay of Interferon by the Immunofluorescent Cell-counting Technique

, 1969
Edmund H. Kozikowski, Nicholas Hahon
openalex   +1 more source

Interferon Production by Human Leukocytes In Vitro: Some Biological Characteristics1 [PDF]

, 1969
Spencer H. S. Lee
openalex   +1 more source