Results 211 to 220 of about 582,181 (313)

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Data from PP2Ac Deficiency Enhances Tumor Immunogenicity by Activating STING-Type I Interferon Signaling in Glioblastoma

Isha Mondal, Oishika Das, Raymond Wai‐Yin Sun, Gao Jian, Bohyeon Yu, Aarón Díaz, Jinan Behnan, Abhishek Dubey, Zhipeng Meng, Emad N. Eskandar, Beisi Xu, Rongze Lu, Winson S. Ho   +12 more
openalex   +1 more source

Beyond CD30: Dual‐Targeting of Malignant and Regulatory T Cells by Brentuximab Vedotin Remodels the Lymphoma Microenvironment and Overcomes Resistance via BCL2 Inhibition in Mycosis Fungoides

Advanced Science, EarlyView.
Single‐cell RNA analyses of paired lesions from CD30+ mycosis fungoides patients demonstrate that brentuximab vedotin (BV) induces immunogenic cell death in both CD30+ and CD30− malignant T cells. BV also targets regulatory T cells and remodels tumor microenvironment, while resistance is driven by impaired IFN responses, drug efflux, and BCL2 ...
Yi Jiang, Pan Lai, Mingjia Li, Yujie Wen, Mengzhou Cao, Yu Xiao, Zhuojing Chen, Jingru Sun, Yang Wang   +8 more
wiley   +1 more source

<i>Lactiplantibacillus plantarum</i> GUANKE Enhances Antiviral Defense Against Respiratory Syncytial Virus Through the STING-TBK1-IRF3-IFN Pathway. [PDF]

Nutrients
Yue K, Lu S, Ma H, Mi J, Fan Q, Yang T, Huang Y, Song L, Ren Z, Ren L, Xu J.   +10 more
europepmc   +1 more source

Supplementary Figure 8 from MYC induces immunotherapy and interferon-γ resistance through downregulation of JAK2

Ettai Markovits, Ortal Harush, Erez N. Baruch, Eldad D. Shulman, Assaf Debby, Orit Itzhaki, Liat Anafi, Artem Danilevsky, Noam Shomron, Guy Ben‐Betzalel, Nethanel Asher, Ronnie Shapira‐Frommer, Jacob Schachter, Iris Barshack, Tamar Geiger, Ran Elkon, Michal J. Besser, Gal Markel   +17 more
openalex   +1 more source

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

The inflammatory clock: how cGAS-STING ticks in the aging ovary. [PDF]

Front Cell Dev Biol
Ma Y, Chen Y, Yuan X, Li T, Luo H, Gu Y.
europepmc   +1 more source

PACT- and RIG-I-Dependent Activation of Type I Interferon Production by a Defective Interfering RNA Derived from Measles Virus Vaccine

, 2015
Ting‐Hin Ho, Chun Kew, Pak‐Yin Lui, Chi‐Ping Chan, Takashi Satoh, Shizuo Akira, Dong‐Yan Jin, Kin‐Hang Kok   +7 more
openalex   +1 more source

Hypofractionated Radiotherapy Induces ISG15+MHC‐I+ Neutrophils to Augment Anti‐Tumor Immunity and Prime Immune Checkpoint Blockade Responses in Rectal Cancer

Advanced Science, EarlyView.
ABSTRACT Our previous clinical trials had demonstrated that neoadjuvant hypofractionated radiotherapy (HFRT) combined with immunotherapy yields promising clinical outcomes in locally advanced rectal cancer (LARC). However, this combined modality benefits only a subset of patients, highlighting the need to uncover the mechanisms underlying how ...
Lichao Liu, Haihong Wang, Mingjie Li, Qian Xu, Linlin Zheng, Chaoqun Han, Zhenwei Zou, Jinghua Ren, Xiaorong Dong, Peng Zhang, Kaixiong Tao, Zhenyu Lin, Tao Zhang   +12 more
wiley   +1 more source

miR-194-5p targets SOCS2 to predict pegIFNα treatment response in HBeAg-positive chronic hepatitis B patients. [PDF]

Virol J
Chen Y, LijuanZhang, Ling L.
europepmc   +1 more source