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Interferon a-2a and Interferon a-2b [PDF]
Hospital Pharmacy, 1999 The increasing complexity of cancer chemotherapy makes it mandatory that pharmacists be familiar with these highly toxic agents. This column reviews various issues related to the preparation, dispensing, and administration of cancer chemotherapy, both commercially available and investigational.
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Classification of interferons with antibody to immune interferon
Cellular Immunology, 1980Abstract Mouse immune Interferon, induced by the T-cell mitogen staphylococcal enterotoxin A (SEA), was partially purified and used to immunize rabbits. The resulting antiserum neutralized all immune interferon preparations tested, including interferon induced in vitro by SEA, concanavalin A, phytohemagglutinin P, and pokeweed mitogen, and in mixed ...
Osborne, L C +2 more
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Effect of Interferon on Early Interferon Production
Science, 1966Chick embryo cells given prior treatment with interferon make new interferon earlier and in larger quantities upon stimulation with Chikungunya virus than cells not so treated. By the criterion of loss of sensitivity to actinomycin, the time needed for formation of messenger RNA for interferon was decreased in the primed cells.
Charles E. Buckler +2 more
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Interferons, interferon‐like cytokines, and their receptors
Immunological Reviews, 2004Summary: Recombinant interferon‐α (IFN‐α) was approved by regulatory agencies in many countries in 1986. As the first biotherapeutic approved, IFN‐α paved the way for the development of many other cytokines and growth factors. Nevertheless, understanding the functions of the multitude of human IFNs and IFN‐like cytokines has just touched the surface ...
Mark R. Walter +2 more
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Interferon receptors and their role in interferon action
Experientia, 1989Interferon (IFN) proteins interact with cells through specific cell surface receptors, some of which have been purified and cloned. The alpha-IFNs and beta-IFN bind to a common receptor (type I), whereas gamma-IFN binds to a separate receptor (type II).
J. L. Taylor +2 more
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Current Concepts of Interferon and Interferon Induction
Annual Review of Medicine, 1970Although viral interference was described some 30 years ago (1, 2), the role of a specific protein, called "interferon," in the resistance to viral in fection was noted by Isaacs & Lindenmann (3) in 1957. Interferon appears to be a stable, nontoxic, potent, broadly active substance which is produced early in viral infection and functions at the ...
Erik De Clercq, Thomas C. Merigan
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