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Interferons, interferon‐like cytokines, and their receptors
Immunological Reviews, 2004Summary: Recombinant interferon‐α (IFN‐α) was approved by regulatory agencies in many countries in 1986. As the first biotherapeutic approved, IFN‐α paved the way for the development of many other cytokines and growth factors. Nevertheless, understanding the functions of the multitude of human IFNs and IFN‐like cytokines has just touched the surface ...
Mark R. Walter +2 more
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Interferon receptors and their role in interferon action
Experientia, 1989Interferon (IFN) proteins interact with cells through specific cell surface receptors, some of which have been purified and cloned. The alpha-IFNs and beta-IFN bind to a common receptor (type I), whereas gamma-IFN binds to a separate receptor (type II).
J. L. Taylor +2 more
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Current Concepts of Interferon and Interferon Induction
Annual Review of Medicine, 1970Although viral interference was described some 30 years ago (1, 2), the role of a specific protein, called "interferon," in the resistance to viral in fection was noted by Isaacs & Lindenmann (3) in 1957. Interferon appears to be a stable, nontoxic, potent, broadly active substance which is produced early in viral infection and functions at the ...
Erik De Clercq, Thomas C. Merigan
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Cellular responses to interferon-gamma.
Annual Review of Immunology, 1997U. Boehm, T. Klamp, M. Groot, J. Howard
semanticscholar +1 more source
Critical Determinants of Cytokine Storm and Type I Interferon Response in COVID-19 Pathogenesis
Clinical Microbiology Reviews, 2021Selvakumar Subbian
exaly