Results 201 to 210 of about 1,226,213 (336)

Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

Advanced Science, EarlyView.
This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu, Ruotong Li, Li Zhang, Hengli Lu, Binhui Yang, Qian Hu, Yining Tao, Haoran Mu, Jing Han, Pengfei Zan, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Wei Sun, Xingjun Zhu   +14 more
wiley   +1 more source

Quinovic Acid Enhances the Cytotoxicity of KHYG-1 Cells by Modulating the Ras/MAPK Signalling Pathway and Interferon-Gamma Expression. [PDF]

J Cell Mol Med
Hsieh MJ, Lin JT, Chuang YC, Ho HY, Lo YS, Lin CC, Chen MK.   +6 more
europepmc   +1 more source

Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

Proceedings of the National Academy of Sciences of the United States of America, 1993
R. Gazzinelli, S. Hieny, T. Wynn, S. Wolf, A. Sher   +4 more
semanticscholar   +1 more source

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

Advanced Science, EarlyView.
This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta, Jonas Bossart, Sènan Mickael D'Almeida, Luis Augusto Visani de Luna, Christoph Schwärzler, Tingting Fu, Vanesa Ayala‐Nunez, Alexander Gogos, Marija Buljan, Vera M Kissling, Emmanuel Flahaut, Miguel Garcia, Cyrill Bussy, Peter Wick, Tina Buerki‐Thurnherr   +14 more
wiley   +1 more source

Clinical course and outcomes of patients with anti-interferon-gamma autoantibody-associated adult-onset immunodeficiency: an observational cohort study. [PDF]

Ann Med
Angkasekwinai N, Wongsawat E, Vorasan N.
europepmc   +1 more source

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.

Proceedings of the National Academy of Sciences of the United States of America, 1993
C. Tripp, S. Wolf, E. Unanue
semanticscholar   +1 more source

Genome‐Wide Codon Reprogramming Enables a Multifactorially Attenuated Influenza Vaccine with Broad Cross‐Protection

Advanced Science, EarlyView.
Genome‐wide codon reprogramming of influenza A virus introduces 1956 synonymous mutations across five segments and elevates CpG content, causing defective NA packaging, loss of NS1 accumulation, and enhanced ZAP‐mediated antiviral responses without affecting RNA or protein synthesis. These mechanisms result in profound attenuation and potent homologous
Yang Wang, Tianxin Ma, Yujiao He, Qinming Li, Kailin Mai, Minying Mo, Chenyang Cao, Jiahui Li, Pei Feng, Jiaojiao Peng, Jing Sun, Weiqi Pan, Zifeng Yang, Ling Chen   +13 more
wiley   +1 more source

Interferon gamma rebalances immunopathological signatures in chronic granulomatous disease through metabolic rewiring. [PDF]

Blood Adv
Bruno M, Kröger C, Ferreira AV, Zhang B, Röring RJ, Liu R, van der Made CI, van Rhijn N, Groh L, Klück V, Janssen NAF, Li W, Rosati D, Alaswad A, Tercan H, Saiz J, Gonzalez-Riano C, van Uelft M, Gaal OI, Müller S, Ferreira HJ, Warnat-Herresthal S, Becker M, Holsten L, Kraut M, Schulte-Schrepping J, Bonaguro L, Händler K, Cunha C, Schmolz M, Schultze JL, Joosten LAB, Barbas C, Netea MG, Li Y, Aschenbrenner AC, Carvalho A, van de Veerdonk FL.   +37 more
europepmc   +1 more source

USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer

Advanced Science, EarlyView.
USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen, Ling Wang, Hongmei Fan, Lisheng Li, Lingyu Zhang, Ruoxin Li, Fang Liu, Fuli Wen, Yunbin Ye, Chuanzhong Huang   +9 more
wiley   +1 more source

Variable clinical features and delayed diagnosis in six Chinese patients with anti-interferon-gamma autoantibodies: a retrospective analysis in a university hospital in China. [PDF]

BMC Immunol
Zhang J, Ni J, Kong W, Liu J, Chen Y.
europepmc   +1 more source