Results 151 to 160 of about 128,935 (252)

Immune checkpoint blockade as an accelerator of adrenal aging: a testable model linking low-grade cortical inflammation to proteostasis failure, LDLR/SULT2A1 suppression, and reduced DHEA output. [PDF]

J Immunother Cancer
Ding G, Xu Y, Guo T, Feng C.
europepmc   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Octreotide Counteracts IFN-γ-Induced Endothelial Inflammation. [PDF]

J Biochem Mol Toxicol
Fakir S, Sigdel M, Sarker MMR, Barabutis N.   +3 more
europepmc   +1 more source

Comparative Analysis of Salmonella typhimurium‐Induced Transcriptomic Changes in the Spleen of Beijing‐You Chickens and Guang Ming Broilers

Animal Research and One Health, EarlyView.
This study analyzed the spleen transcriptomes of different chicken breeds, identified key differentially expressed genes (EGR1, FOS, and DUSP1) that regulate resistance to Salmonella infection, and elucidated the underlying regulatory mechanisms, thereby providing new targets for disease‐resistant breeding in poultry.
Zixuan Wang, Man Deng, He Geng, Jumei Zheng, Xiang Li, Yaping Wang, Qinghe Li, Guiping Zhao, Qiao Wang   +8 more
wiley   +1 more source

Differential cytokine architecture in patients treated with CART19 versus CART22. [PDF]

J Immunother Cancer
Diorio C, Shraim R, Thadi A, Frank-Kamenetskii A, Uppuluri L, Klinghoffer H, Martinez Z, Babu A, Myers RM, Fraietta JA, Hughes A, Sussman J, Xu J, McClory SE, Mueller K, Perazzelli J, Vella LA, Henrickson SE, Ruella M, Behrens EM, DiNofia AM, Burkhardt JK, Maude SL, Canna S, Tan K, Grupp S, Teachey DT.   +26 more
europepmc   +1 more source

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

Interferon gamma applied ex vivo restores function to neutrophils from critically ill patients. [PDF]

Thorax
Lake CJ, Scott J, Ruchaud-Sparagano MH, Thompson JH, Dewar F, Yarova P, Funston W, Davidson RC, Musgrave KM, Wright SE, Clement I, Roy AI, Sendama W, Powell J, Brooks D, Lin CMA, Davies K, Hellyer TP, Rostron AJ, Simpson AJ.   +19 more
europepmc   +1 more source

Investigating the Role of Type I Interferon Signaling on Muscle Disease Using Mouse Models

Arthritis &Rheumatology, EarlyView.
Objective Dysregulated type I interferon (IFN) signaling contributes to autoimmune myositis pathogenesis. We investigated the therapeutic effects of JAK inhibitors in two mouse models. We also examined how type I IFNs affect muscle vasculature. Methods Myositis was induced in major histocompatibility complex class I double transgenic ([TRE‐H‐2Kb (H ...
Rita Spathis, Sabrina Narvesen, Deeva Robles Kuriplach, Karen Huang, Teja Sundar, Elizabeth Bagley, Joanna Parkes, Xinyu Jia, Nandhana Sudhan, Alfredo Guzman, Kanneboyina Nagaraju, Melissa Morales   +11 more
wiley   +1 more source

Genetic mechanisms underlying host susceptibility to central nervous system viral infections. [PDF]

Curr Opin Infect Dis
Benjamin R, Pandya D, Nath A.
europepmc   +1 more source