Innate Intracellular Antiviral Responses Restrict the Amplification of Defective Virus Genomes of Parainfluenza Virus 5. [PDF]
, 2020 During the replication of parainfluenza virus 5 (PIV5), copyback defective virus genomes (DVGs) are erroneously produced and are packaged into "infectious" virus particles.
Goodbourn, S +6 more
core +3 more sources
Porcine innate and adaptative immune responses to influenza and coronavirus infections [PDF]
, 2006 Both innate and adaptative immune responses contribute to the control of infectious diseases, including by limiting the spreading of zoonotic diseases from animal reservoirs to humans.
Asselin-Paturel +35 more
core +2 more sources
Drug-Drug Interactions Among Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) Medications [PDF]
, 2015 One-fourth of individuals diagnosed with the human immunodeficiency virus concomitantly have the hepatitis C virus infection. Since the discovery of highly active antiretroviral therapy, liver complications have become the leading cause of morbidity and ...
Gandhi, Mona A. +2 more
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Forging a potent vaccine adjuvant: CpG ODN/cationic peptide nanorings [PDF]
, 2014 Cataloged from PDF version of article.Type I interferon inducers may potentially be engineered to function as antiviral and anticancer agents, or alternatively, vaccine adjuvants, all of which may have clinical applications.
Gungor, B. +3 more
core +1 more source
The NS3 protein of rice hoja blanca virus suppresses RNA silencing in mammalian cells [PDF]
, 2008 The NS3 protein of the tenuivirus rice hoja blanca virus (RHBV) has previously been shown to represent the viral RNA interference (RNAi) suppressor and is active in both plant and insect cells by binding short interfering RNAs (siRNAs) in vitro.
Goldbach, R.W. +3 more
core +2 more sources
The pestivirus N terminal protease N(pro) redistributes to mitochondria and peroxisomes suggesting new sites for regulation of IRF3 by N(pro.) [PDF]
, 2014 The N-terminal protease of pestiviruses, N(pro) is a unique viral protein, both because it is a distinct autoprotease that cleaves itself from the following polyprotein chain, and also because it binds and inactivates IRF3, a central regulator of ...
C Achmüller +36 more
core +5 more sources
Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection. [PDF]
, 1994 Leishmania major are intramacrophage parasites whose eradication requires the induction of T helper 1 (Th1) effector cells capable of activating macrophages to a microbicidal state.
Locksley, RM +4 more
core +1 more source
Truncation of the NS1 protein converts a low pathogenic avian influenza virus into a strong interferon inducer in duck cells [PDF]
, 2010 The NS1 protein of influenza A viruses is known as a nonessential virulence factor inhibiting type I interferon (IFN) production in mammals and in chicken cells. Whether NS1 inhibits the induction of type I IFNs in duck cells is currently unknown.
Guérin, Jean-Luc +3 more
core +1 more source
An unbiased genetic screen reveals the polygenic nature of the influenza virus anti-interferon response. [PDF]
, 2014 Influenza A viruses counteract the cellular innate immune response at several steps, including blocking RIG I-dependent activation of interferon (IFN) transcription, interferon (IFN)-dependent upregulation of IFN-stimulated genes (ISGs), and the activity
Asensio, VJ +7 more
core +2 more sources
Antigen presenting capacity of murine splenic myeloid cells [PDF]
, 2017 BACKGROUND: The spleen is an important site for hematopoiesis. It supports development of myeloid cells from bone marrow-derived precursors entering from blood. Myeloid subsets in spleen are not well characterised although dendritic cell (DC) subsets are
Hey, Ying-Ying +2 more
core +2 more sources