Results 31 to 40 of about 201,455 (289)

TPNA10168, an Nrf-2 activator, attenuates inflammatory responses independently of Nrf2 in microglial BV-2 cells: Involvement of the extracellular-signal-regulated kinase pathway

Journal of Pharmacological Sciences, 2022
Some chemical Nrf2 inducers possess antioxidant and anti-inflammatory properties. TPNA10168, which was identified from a chemical library as a potential activator of the Keap1-Nrf2-ARE pathway, exhibits a neuroprotective effect against oxidative stress ...
Yasuhiko Izumi, Ai Tatsumoto, Naoko Horiuchi, Monami Arifuku, Momoko Uegomori, Toshiaki Kume, Yutaka Koyama   +6 more
doaj   +1 more source

An unbiased genetic screen reveals the polygenic nature of the influenza virus anti-interferon response [PDF]

, 2014
Influenza A viruses counteract the cellular innate immune response at several steps, including blocking RIG I-dependent activation of interferon (IFN) transcription, IFN-dependent upregulation of IFN-stimulated genes (ISGs) and the activity of various ...
Fernández, Yolanda, Oliveros, JC, Randall, Richard E, Asensio, Víctor J, Killip, Marian J., Randall, RE, Oliveros, Juan Carlos, Killip, Marian J, Asensio, Víctor J., Bengoechea, Jose Antonio, Oliveros, Juan C., Pérez-Cidoncha, Maite, Pérez-Cidoncha, M, Bengoechea, JA, Bengoechea, José A; id_orcid, Ortín, Juan, Killip, MJ, Ortín, J, Asensio, Víctor José, Randall, Richard E., Bengoechea, José A., Asensio, VJ, Oliveros, Juan C, Fernández, Y, Randall, Richard E.; id_orcid   +24 more
core   +1 more source

Innate sensing of HIV-infected cells [PDF]

, 2011
Cell-free HIV-1 virions are poor stimulators of type I interferon (IFN) production. We examined here how HIV-infected cells are recognized by plasmacytoid dendritic cells (pDCs) and by other cells.
Richard E. Randall, Randall, Richard E, Mustapha Si-Tahar, Helen K W Law, Julien Pothlichet, Plumas, Joel, Lepelley, Alice, Mammano, Fabrizio, Helen K. W. Law, Richard E Randall, Schwartz, Olivier, Albert, Matthew L, Albert, Matthew L., Louis, Stephanie, Laurence Chaperot, Chaperot, Laurence, Stéphanie Louis, Pothlichet, Julien, Olivier Schwartz, Si-Tahar, Mustapha, Sourisseau, Marion, Schilte, Clementine, Law, Helen K. W., Law, Helen K W, Marion Sourisseau, Joël Plumas, Alice Lepelley, Clémentine Schilte, Fabrizio Mammano, Matthew L Albert, Matthew L. Albert, Randall, Richard Edward, Randall, Richard Edward; id_orcid   +32 more
core   +2 more sources

Regulation of gene expression by cytokines and virus in human cells lacking the type‐I interferon locus

, 1992
A number of genes that are induced by type‐I interferons are also activated by one or more other inducers, including double‐stranded RNA, viruses, interferon‐γ, interleukin‐1 and tumor necrosis factor.
Wathelet, Marc, Pascale M. BERR, Georges A. HUEZ, Berr, Pascale, Huez, Georges, Marc G. WATHELET   +5 more
core   +1 more source

Antiviral and interferon-inducing properties of interferon inducers administered with prostaglandins [PDF]

Antimicrobial Agents and Chemotherapy, 1980
Prostaglandins enhanced the interferon response and therapeutic activity of interferon inducers in Friend leukemia virus-infected mice. A similar enhancement in interfron responsiveness but not antiviral activity was observed in mice infected with rapidly acute viruses.
openaire   +2 more sources

The Use of Interferon Inducers in an Infectious Disease Clinic

Антибиотики и Химиотерапия, 2020
The article presents the scientific substantiation of the use of interferon inducers in an infectious disease clinic the inducers of endogenous interferon of various chemical groups with antiviral action are examined and analyzed.
A. A. Shuldyakov, E. P. Lyapina, L. A. Soboleva, M. G. Romantsov, T. A. Perminova, V. I. Kuznetsov, L. S. Narkaitis   +6 more
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Study of the Dynamics and the Level of Accumulation of Interferon in the Serum of Laboratory Animals

Антибиотики и Химиотерапия, 2020
Studies have shown that high-molecular inducers of interferon Larigan®, Ridostin®, and Rifastin cause «early» interferon production which amounts to maximum 3 hours after injection.
S. Ja. Loginova, V. N. Shchukina, S. V. Borisevich   +2 more
doaj  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source