Results 91 to 100 of about 35,830 (194)

PRMT5 Inhibitor Synergizes with Chemotherapy to Induce Resembling Mismatch Repair Deficiency and Enhance Anti‐TIGIT Therapy in Microsatellite‐Stable Colorectal Cancer

Advanced Science, EarlyView.
Microsatellite‐stable (MSS) colorectal cancer (CRC) resists immunotherapy. PRMT5 inhibition enhances CPT‐11 sensitivity, inducing a PMS2‐deficient‐like state and cytosolic dsDNA release, which activates the cGAS‐STING pathway to promote anti‐tumor immunity. However, this combination therapy upregulates TIGIT expression on CD8+ T cells, and the addition
Jiang Zhu, Shenao Fu, Xi Zou, Hanjiang Zeng, Guangzu Cui, Yinghui Peng, Diya Tang, Fan Zhang, Hong Shen, Shan Zeng, Ying Han   +10 more
wiley   +1 more source

Identification of CD38high Monocyte as a Candidate Diagnostic Biomarker and Therapeutic Target for Sepsis

Advanced Science, EarlyView.
This study uncovers that CD38high monocytes discriminate sepsis and sterile inflammation and are associated with 28‐day mortality in bacterial sepsis. Targeting CD38 therapy reduces inflammatory response in monocytes and in sepsis mice model. Mechanistically, CD38‐HIF‐1α/glycolysis/MGO loop exacerbates sepsis‐induced immune dysregulation.
Ning Hua, Limin Kong, Li Fan, Yanan Bai, Yujun Zhou, Yanfang Zhang, Qingwei Zhao, Xiaoyang Lu, Hongyu Yang, Hangyang Li, Peili Ding, Yuyu Nan, Qinghua Ji, Ping Yang, Lu Li, Yijing Xin, Lijuan Zhao, Wei Yang, Wenqiao Yu, Saiping Jiang   +19 more
wiley   +1 more source

Development and testing of a mouse simulated space flight model [PDF]

The development and testing of a mouse model for simulating some aspects of weightlessness that occurs during space flight, and the carrying out of immunological experiments on animals undergoing space flight is examined. The mouse model developed was an
Sonnenfeld, Gerald
core   +1 more source

CCN1 Enhances Tumor Immunosuppression through Collagen‐Mediated Chemokine Secretion in Pancreatic Cancer

Advanced Science, EarlyView.
CCN1 modulates the tumor microenvironment in pancreatic cancer by promoting collagen‐dependent chemokine production, thereby facilitating immune evasion. Deletion of CCN1 not only suppresses tumor growth but also enhances immune cell infiltration and increases tumor sensitivity to both chemotherapy and immunotherapy.
Hongjie Fan, Huzi Zhao, Lili Gao, Yucheng Dong, Pei Zhang, Pengfei Yu, Yunfei Ji, Zhe‐Sheng Chen, Xinmiao Liang, Yang Chen   +9 more
wiley   +1 more source

Regulation of immunogenic cell death and potential applications in cancer therapy. [PDF]

Front Immunol
Fang K, Yuan S, Zhang X, Zhang J, Sun SL, Li X.   +5 more
europepmc   +1 more source

Detection of autoantibodies against exocrine pancreas by double immunodiffusion testing [PDF]

, 1990
Horbach, E., Kaiser, Doris, Otte, M., Rögener, W., Scriba, Peter Christian, Stöcker, W.   +5 more
core  

Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice [PDF]

, 2017
Aagaard, Barrows, Bayer, Bin Cao, Cadwell, Cao, Cao, Cao-Lormeau, Cemma, Chibueze, Chiramel, Delorme-Axford, Delvecchio, El Costa, Elfiky, Eyer, Farias, Hamel, Indira U. Mysorekar, Jurado, Kaplan, Khan, Klionsky, Lamont, Lennemann, Levine, Liang, Lindsay A. Parnell, Martín-Acebes, Mateo, Michael S. Diamond, Miner, Mysorekar, Pirooz, Quicke, Rosenfeldt, Rossant, Sacramento, Savarino, Sharma, Shoji-Kawata, Signorelli, Tabata, Tricou, Vandergaast, Vermillion, Wenzel, Xu, Yockey, Zmurko   +49 more
core   +2 more sources

Bimetallic Ca/Zn Nanoagonist Remould the Immunosuppressive Hepatocellular Carcinoma Microenvironment Following Incomplete Microwave Ablation via Pyroptosis and the STING Signaling Pathway

Advanced Science, EarlyView.
The multifunctional bimetallic Ca/Zn nanoagonist (PZH/Zn@CaNA) significantly downregulated the JAK2‐STAT3 signaling pathway, which effectively inhibited the proliferation and growth of HCC with incomplete microwave ablation. Furthermore, the released bimetallic ions (Ca2⁺ and Zn2⁺) synergistically enhanced oxidative stress‐mediated cytotoxicity ...
Yuan Ling, Xiayi Liang, Kangning Yan, Guichun Zeng, Xiaoqi Zhu, Jinghang Jiang, Shaolong Lu, Xiaobo Wang, Yuying Zhou, Zhaoshen Li, Wei Mai, Duo Wang, Jie Chen   +12 more
wiley   +1 more source

Tumor immunology: a short IL18 cleavage product promotes cancer immunosurveillance. [PDF]

Signal Transduct Target Ther
Guilbaud E, Galluzzi L.
europepmc   +1 more source

Autoantibodies against cerebral gray matter in patients with insulin dependant diabetes mellitus [PDF]

, 1990
Kömpf, D., Schaper, J., Schuhose, C., Scriba, Peter Christian, Stöcker, W., Vieregge, P.   +5 more
core