Results 91 to 100 of about 50,714 (355)

Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini, Paolo Preziosa, Paola Valsasina, Damiano Mistri, Monica Margoni, Federica Esposito, Massimo Filippi, Maria A. Rocca   +7 more
wiley   +1 more source

The MMP‐9/TIMP‐1 Ratio and Concentrations of Osteopontin Are Elevated in Cerebrospinal Fluid of People With Multiple Sclerosis and Decrease After Autologous Hematopoietic Stem Cell Transplantation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the utility of cerebrospinal fluid (CSF) biomarkers—matrix metalloproteinase‐9 (MMP‐9), tissue inhibitor of metalloproteinases‐1 (TIMP‐1), the MMP‐9/TIMP‐1 ratio, and osteopontin (OPN)—as indicators of blood–brain barrier (BBB) integrity and disease activity in people with relapsing–remitting multiple sclerosis (pwMS ...
Ivan Pavlovic, Ida Erngren, Kim Kultima, Anders Larsson, Malin Müller, Anna Wiberg, Joachim Burman   +6 more
wiley   +1 more source

New diagnostic and treatment perspectives of children’s hepatic lesions

Журнал инфектологии, 2014
This review presents the current possibilities of diagnosis of children’s liver disease: to define avidity of antibodies to hepatitis A, C for detection early infection, the development of non-invasive panel of serum markers of fibrosis and the ...
Yu. V. Lobzin, L. G. Goryacheva, N. V. Rogozina, N. A. Efremova, M. Ya. Kotiv, A. L. Mukomolova   +5 more
doaj   +1 more source

The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice [PDF]

, 1996
MRL/MP-lpr/lpr (MRL/lpr) mice develop a spontaneous autoimmune disease. Serum from these mice contained significantly higher concentrations of nitrite/nitrate than serum from age-matched control MRL/MP-+/+ (MRL/+), BALB/c or CBA/6J mice.
Feng, G.J., Huang, F.P., Liew, F.Y., Lindop, G., Stott, D.I.   +4 more
core   +3 more sources

Network Localization of Fatigue in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo, Jaakko Kungshamn, Albert Bellmunt‐Gil, Silvia Tommasin, Abhineet Ojha, Matias Viitala, Juho Aaltonen, Jyrki Lötjönen, Juha Koikkalainen, Pauli Ylikotila, Patrizia Pantano, Merja Soilu‐Hänninen, Juho Joutsa   +12 more
wiley   +1 more source

Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells

Respiratory Research, 2005
Background Fatal human respiratory disease associated with influenza A subtype H5N1 has been documented in Hong Kong, and more recently in Vietnam, Thailand and Cambodia. We previously demonstrated that patients with H5N1 disease had unusually high serum
Poon LLM, Long HT, Chan RWY, Chan YO, Nicholls JM, Tsao SW, Chui WH, Cheung CY, Chan MCW, Guan Y, Peiris JSM   +10 more
doaj   +1 more source

Антивирусная и интерферониндуцирующая активность новых соединений – производных индолхиноксалинов [PDF]

, 2016
Проблематика. Розробка нових препаратів з антивірусною активністю та здатністю індукувати інтерферон є актуальним завданням з огляду на стрімке поширення вірусних інфекцій, формування резистентних до існуючих антивірусних препаратів штамів вірусів ...
Bogun, T. A., Bykova, T. I., Spivak, M. Ya., Zholner, G. G., Zholobak, N. M., Бикова, Тетяна Іванівна, Богун, Т. А., Богун, Тетяна Андріївна, Быкова, Т. И., Жолнер, Л. Г., Жолнер, Лілія Григорівна, Жолобак, Н. М., Жолобак, Надія Михайлівна, Спивак, Н. Я., Співак, Микола Якович   +14 more
core   +1 more source

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

Transcriptional activity of TLR/RLR receptor genes in macrophage-like cells under the influence of drugs based on acridoneacetic acid

Медицинская иммунология
Activation of Toll-like receptors (TLRs) is one of the earliest indicators of functional activation of the innate immune system. Therefore, the development of drugs that stimulate the transcription of TLR/RLR genes and at the same time are “multi-target”
A. N. Narovlyansky, V. V. Poloskov, M. V. Mezentseva, I. A. Suetina, A. V. Tsvetnov, E. Yu. Bogdanov, I. T. Fedyakina, A. L. Kovalenko, F. I. Ershov   +8 more
doaj   +1 more source

Type I and II interferons induce granulopoiesis and correlate with organ damage during infection-induced shock [PDF]

, 2023
Amber Bahr, Jennifer Howard, Kate MacNamara   +2 more
openalex   +1 more source