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Immune Delay, Beyond Immune Evasion, as a Driver of Pathogen Propagation Competence Through Neutrophil Dysregulation, to be Mitigated by Low-Frequency Electromagnetic Fields (LF-EMF). [PDF]
Int J Mol SciCuppen JJM, Savelkoul HFJ.
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Interleukin-36 upregulates type-I interferon responses in systemic lupus erythematosus by promoting the accumulation of self-nucleic acids. [PDF]
Front ImmunolWelsh EJ +4 more
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Recent advances in targeting the cGAS-STING pathway for immunotherapy in orthopedic diseases. [PDF]
Front ImmunolWu F, Hui S, Li D, Pan G, Zhang W.
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Type I Interferons in Autoimmunity
Journal of Investigative Dermatology, 2022Dysregulated IFN-1 responses play crucial roles in the development of multiple forms of autoimmunity. Many patients with lupus, systemic sclerosis, Sjogren's syndrome, and dermatomyositis demonstrate enhanced IFN-1 signaling. IFN-1 excess is associated with disease severity and autoantibodies and could potentially predict response to newer therapies ...
Ruth Fernandez-Ruiz, Timothy B. Niewold
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International Reviews of Immunology, 1998
Type I interferons (IFNs) constitute a family of structurally related proteins that are all derived from the same ancestral gene and act on a common cell-surface receptor. Contrary to many other cytokines, the production of type I IFNs is not a specialized function, and all cells in the organism can produce them, usually as a result of induction by ...
E, De Maeyer, J, De Maeyer-Guignard
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Type I interferons (IFNs) constitute a family of structurally related proteins that are all derived from the same ancestral gene and act on a common cell-surface receptor. Contrary to many other cytokines, the production of type I IFNs is not a specialized function, and all cells in the organism can produce them, usually as a result of induction by ...
E, De Maeyer, J, De Maeyer-Guignard
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Current Opinion in Rheumatology, 2009
Patients with lupus have signs of an ongoing production of type I interferons (IFNs) that are of importance both for the etiopathogenesis and the clinical manifestations. In this review, we summarize the latest information concerning the type I IFN system in lupus.Activated plasmacytoid dendritic cells are responsible for the IFNalpha production in ...
Lars, Rönnblom +2 more
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Patients with lupus have signs of an ongoing production of type I interferons (IFNs) that are of importance both for the etiopathogenesis and the clinical manifestations. In this review, we summarize the latest information concerning the type I IFN system in lupus.Activated plasmacytoid dendritic cells are responsible for the IFNalpha production in ...
Lars, Rönnblom +2 more
openaire +2 more sources