Results 351 to 360 of about 1,888,881 (401)
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Validation of an Interferon Type I Score Test on the Nanostring nCounter Platform
Journal of Human ImmunityType I interferons have wide-ranging impact on the immune system in response to viruses, bacteria, and parasites. However, excessive and uncontrolled levels could lead to various autoimmunity and autoinflammatory conditions, a subset of which have been ...
Samuel Chiang +7 more
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Type I and Type II Interferon Receptors
Journal of Interferon Research, 1984Binding site competition studies of 125I-interferon (IFN)-gamma were performed with homogeneous preparations of IFNs alpha 2, beta, and gamma. It was found that only IFN-gamma could compete for the specific binding site of 125I-IFN-gamma in both WISH and FS11 cells.
P, Orchansky +3 more
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Type I interferon genes and proteins
Biotherapy, 1996The large number of type I interferon genes in mammalian species could be explained by simple redundancy, by different functions for different interferons, or by different spatial or temporal patterns of expression. Different functions would require different receptors for each interferon, while different patterns of expression would require different ...
M O, Díaz, D, Testa
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Type I-interferon signalling in fish
Fish & Shellfish Immunology, 2002Type I interferon (IFN) signalling uses a dual mechanism of action. A Jak-Stat pathway extensively described in mammals involves a cascade of reactions from the interaction of the IFN molecule with its membrane receptor to the stimulation of IFN-induced gene promoters leading in turn to an antiviral state. Regulation of IFN activity is also mediated by
Bertrand, Collet +1 more
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Measurement of Type I Interferon Production
Current Protocols in Immunology, 2011AbstractThe Basic Protocol in this unit describes measurement of murine interferon (IFN)α/β by intracellular staining for these cytokines and detection by flow cytometry. Alternate protocols detail an enzyme‐linked immunoabsorbent assay (ELISA) for IFNα and a biological assay to measure IFN.
Rosalind E, Seeds, Joanna L, Miller
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Type I Interferons in Autoimmune Disease
Annual Review of Pathology: Mechanisms of Disease, 2019Type I interferons, which make up the first cytokine family to be described and are the essential mediators of antivirus host defense, have emerged as central elements in the immunopathology of systemic autoimmune diseases, with systemic lupus erythematosus as the prototype.
Mary K, Crow +2 more
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Type I interferonopathies: Mendelian type I interferon up-regulation
Current Opinion in Immunology, 2015The concept of grouping Mendelian disorders associated with an up-regulation of type I interferon has only recently been suggested. Here we discuss the progress being made in the delineation and understanding of this novel set of inborn errors of immunity, the human type I interferonopathies.
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Type I interferons: expression and signalization
Cellular and Molecular Life Sciences CMLS, 1998Type I interferon (IFN-A and IFN-B) genes encode a large family of multifunctional secreted proteins involved in antiviral defence, cell growth regulation and immune activation. These cytokines, as a consequence of their biological activities, have been established as effective therapeutic molecules for malignant and viral diseases.
J, Doly, A, Civas, S, Navarro, G, Uze
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Type I interferons in anticancer immunity
Nature Reviews Immunology, 2015Type I interferons (IFNs) are known for their key role in antiviral immune responses. In this Review, we discuss accumulating evidence indicating that type I IFNs produced by malignant cells or tumour-infiltrating dendritic cells also control the autocrine or paracrine circuits that underlie cancer immunosurveillance.
Zitvogel, Laurence +4 more
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Fine tuning type I interferon responses
Cytokine & Growth Factor Reviews, 2013Interferon responses are balanced between protection against pathogens and other disease agents versus toxicity and development of chronic diseases. Optimal outcomes are achieved by regulating the nature, strength and duration of Interferon (IFN) production, IFN-receptor interaction and signalling pathways modulated in a manner appropriate for ...
Paul J, Hertzog, Bryan R G, Williams
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