Results 171 to 180 of about 214,014 (308)

Interferon Action on Parental Semliki Forest Virus Ribonucleic Acid [PDF]

open access: bronze, 1967
Robert M. Friedman   +3 more
openalex   +1 more source

Localized Delivery of the mRNAs Encoding CD47 Inhibitor and Interleukins 12, 15, and 21 Elicits Robust Antitumor Immunity

open access: yesAdvanced Science, EarlyView.
The co‐delivery of mRNAs encoding a CD47 inhibitor and a cytokine cocktail (interleukins 12, 15, and 21) via lipid nanoparticles enables effective localized immunotherapy. This strategy not only suppresses tumor progression but also enhances type 1 conventional dendritic cell (cDC1) differentiation and activates CD8+ T cells, thereby inducing robust ...
Tao Jiang   +14 more
wiley   +1 more source

The puzzling regulation of the interferon signaling system by the p53 tumor suppressor protein. [PDF]

open access: yesCell Mol Life Sci
Będzińska A   +4 more
europepmc   +1 more source

Mengovirus-Induced Cytopathic Effect in L-Cells: Protective Effect of Interferon [PDF]

open access: bronze, 1969
Ashley T. Haase   +3 more
openalex   +1 more source

Integrated Transcriptome and Metabolomics Analyses Show MYC as a Potential Therapeutic Target for Behçet's Uveitis

open access: yesAdvanced Science, EarlyView.
Integrated single‐cell transcriptomic and metabolomic analyses reveal that MYC‐driven glycolysis activates the PI3K‐AKT‐FOXO1 pathway, disrupting Th17/Treg balance and promoting uveitis. MYC inhibition restores immune homeostasis and alleviates disease symptoms.
He Li   +11 more
wiley   +1 more source

Zika virus and the fetal-maternal interface: deciphering the mechanisms of placental infection and implications for pregnancy outcomes. [PDF]

open access: yesEmerg Microbes Infect
Wong SCS   +8 more
europepmc   +1 more source

Single‐Cell and Spatial Transcriptomic Profiling of Penile Squamous Cell Carcinoma Reveals Dynamics of Tumor Differentiation and Immune Microenvironment

open access: yesAdvanced Science, EarlyView.
This study uses single‐nucleus RNA sequencing and spatial transcriptomics to investigate penile squamous cell carcinoma (PSCC). It reveals that PSCC tumor cells mimic normal penile epithelium differentiation, independent of HPV status. The Tum_1 subtype shows basal stem‐like characteristics and promotes invasiveness. HPV‐positive basal stem‐like tumors
Hongjian Song   +37 more
wiley   +1 more source

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