Results 201 to 210 of about 171,612 (313)

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

Interferons and <i>Toxoplasma gondii</i> shape PD-L1 regulation in retinal barrier cells: the critical role of proteases. [PDF]

Front Immunol
Geiller B, Cevallos C, Tsybenko I, Arnoux L, Felder-Schmittbuhl MP, Pfaff AW.   +5 more
europepmc   +1 more source

Transient nasal anti-interferon autoantibodies predict better outcomes in COVID-19 infection 4226 [PDF]

Benjamin Babcock, Astrid Kosters, Devon J. Eddins, M Sophia, Baluyot Donaire, Sannidhi Sarvadhavabhatla, Vivian Pae, Fiona Beltran, Victoria Murray, Gurjot Gill, Guorui Xie, Brian Dobosh, Vincent D. Giacalone, Rabindra Tirouvanziam, Richard P. Ramonell, Scott A. Jenks, Igñacio Sanz, F. Eun‐Hyung Lee, Nadia R. Roan, Sulggi A. Lee, Eliver Ghosn   +20 more
openalex   +1 more source

KRAS Withdrawal in Cholangiocarcinoma Leads to Immune Infiltration and Tumor Regression

Advanced Science, EarlyView.
Cholangiocarcinoma (CCA) driven by oncogenic KRAS depends on its continuous activation for tumor maintenance. Using a conditional KRAS model, the authors show that turning off KRAS triggers rapid tumor regression accompanied by immune cell infiltration and cytokine release. The findings uncover a KRAS–senescence–immune signaling axis and highlight KRAS
Youwei Qiao, Matthew F. Yee, Chaitanya N. Parikh, Boyang Ma, Yueying Cao, Yu‐Huan Shih, Joae Qiong Wu, Marcus Ruscetti, Shun‐Qing Liang, Wen Xue   +9 more
wiley   +1 more source

Interferons Inhibit Ebola Virus Infection of Human Keratinocytes. [PDF]

Viruses
Elliff J, Van Ert H, Sevcik K, Djurkovic MA, Rudd D, Gourronc F, Klingelhutz A, Shtanko O, Maury W.   +8 more
europepmc   +1 more source

Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification

, 2016
Melissa E. Munroe, Rufei Lu, Yan D. Zhao, Dustin Fife, Julie M. Robertson, Joel M. Guthridge, Timothy B. Niewold, George C. Tsokos, Michael P. Keith, John B. Harley, Judith A. James   +10 more
openalex   +2 more sources

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Contrasting immune responses in COVID-19: insights from healthcare workers and infected patients on plasmablast, pDC, and NK cell dynamics. [PDF]

Front Immunol
Martín-Pedraza L, Rodríguez-Martín E, De La Torre-Tarazona E, Moreno E, Pariente-Rodríguez R, Walo-Delgado PE, García-Pérez J, Díaz J, Luna L, Rodríguez-Dominguez M, Galán JC, Geraldine Rita C, Del Amo-de Palacios A, Navarro-Soler R, Fons M, Alcamí J, Moreno S, Villar LM, Serrano-Villar S.   +18 more
europepmc   +1 more source

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

Updates on the Role of Innate Immunity's Pattern Recognition Receptors in Vitiligo Pathogenesis and Therapeutic Potential. [PDF]

Clin Cosmet Investig Dermatol
Feng J, Lu L, He H, Peng Y, Zhang S, Yang L, Liu Y, Wang T.   +7 more
europepmc   +1 more source