Results 211 to 220 of about 171,612 (313)

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Expression Patterns of Interferons and Proinflammatory Cytokines in the Upper Respiratory Tract of Patients Infected by Different Viral Pathogens: Correlation with Age and Viral Load. [PDF]

Biomolecules
Ferrarese R, Novazzi F, Arcari G, Genoni A, Drago Ferrante F, Clementi N, Messali S, Pitrolo AMG, Caccuri F, Piralla A, Caruso A, Baldanti F, Mancini N.   +12 more
europepmc   +1 more source

ETV1 Drives CD4+ T Cell‐Mediated Intestinal Inflammation in Inflammatory Bowel Disease Through Amino Acid Transporter Slc7a5

Advanced Science, EarlyView.
This study identifies the transcription factor ETV1 as a key driver of CD4⁺ T cell‐mediated intestinal inflammation in inflammatory bowel disease (IBD). ETV1 promotes CD4⁺ T cell activation, proliferation, and Th17 differentiation by activating the amino acid transporter SLC7A5, fueling metabolic reprogramming.
Yan Shi, Song Wang, Yuqing Yan, Wei Chen, Yingying Cao, Dafan Chen, Wei Chen, Caiyun Ma, Xinjian Wan   +8 more
wiley   +1 more source

Deucravacitinib for the treatment of moderate-to-severe palmoplantar pustulosis: Results from an early-terminated open-label trial. [PDF]

JAAD Int
Ramessur R, Chiesa Fuxench ZC, Shin D, Mason JB, Mason AC, Papadopoulos M, de Oliveira Wafae BG, Noe MH, Gelfand JM.   +8 more
europepmc   +1 more source

Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon gamma.

, 1988
Yoshisuke Ozaki, Mark Edelstein, David S. Duch   +2 more
openalex   +2 more sources

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

Interferons in Autoimmunity: From Loss of Tolerance to Chronic Inflammation. [PDF]

Biomedicines
Mihaescu G, Gradisteanu Pircalabioru G, Roznovan CN, Ditu LM, Comanici MM, Savu O.   +5 more
europepmc   +1 more source

How the study of children with rheumatic diseases identified interferon‐α and interleukin‐1 as novel therapeutic targets

, 2008
Virginia Pascual, Florence Allantaz, Pinakeen Patel, Karolina Palucka, Damien Chaussabel, Jacques Banchereau   +5 more
openalex   +2 more sources

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

TLR agonists as adjuvants for viral vaccines: mechanisms, applications, and future directions. [PDF]

Front Microbiol
Shao F, Zhu X, Yi M, Gao H, Wu J, Fang R, Xie Y, Han J, Lu H.   +8 more
europepmc   +1 more source