Results 241 to 250 of about 171,612 (313)

Could rituximab revolutionize multiple sclerosis treatment in Brazil? The missed opportunity for fewer relapses and lower costs. [PDF]

Lancet Reg Health Am
Silva GD, Pipek LZ, Oliveira MB, Apóstolos-Pereira SL, Adoni T, Lino AMM, Callegaro D, Castro LHM.   +7 more
europepmc   +1 more source

TRIM38 Suppresses Breast Cancer Progression via Modulating SQSTM1 Ubiquitination and Autophagic Flux

Advanced Science, EarlyView.
TRIM38, an E3 ubiquitin ligase, suppresses breast cancer progression by inhibiting proliferation, migration, and invasion. Downregulated in breast tumor, its loss correlates with poor prognosis. Mechanistically, TRIM38 mediates K63‐linked ubiquitination of SQSTM1/p62 at K420, disrupting SQSTM1‐LC3 interaction and blocking autophagic flux.
Shan Jiang, Lijuan Wang, Dianwen Han, Peng Su, Bing Chen, Wenjing Zhao, Tong Chen, Ning Zhang, Xiaolong Wang, Yiran Liang, Yaming Li, Chen Li, Xi Chen, Dan Luo, Qifeng Yang   +14 more
wiley   +1 more source

Toll-like Receptors in Inborn Errors of Immunity in Children: Diagnostic Potential and Therapeutic Frontiers-A Review of the Latest Data. [PDF]

Cells
Jurczuk A, Bałdyga P, Płoński A, Jurczuk M, Garley M.   +4 more
europepmc   +1 more source

Disrupting the Formation of YAP Condensates Promotes the Activation of AMPKα to Inhibit the Progression of Primary Liver Cancer

Advanced Science, EarlyView.
This study systematically investigates the function and molecular mechanisms of YAP phase separation in multiple primary liver cancers. These findings provide novel insights into phase separation‐mediated primary liver cancer development and validate targeted disruption of this process as an effective therapeutic strategy for primary liver cancer ...
Shuang‐Zhou Peng, Jia‐Jia Liang, Yun‐Feng Zhan, Wei‐Xun Wu, Wan‐Li Xu, Xiao‐Kun Zhang, Li‐Jun Cai, Fu‐Quan Jiang   +7 more
wiley   +1 more source

Phyto-derived interferons: a promising frontier in antiviral therapy development. [PDF]

EXCLI J
Venkidasamy B, Balaraman AK, Thiruvengadam M.   +2 more
europepmc   +1 more source

Interferon-Based Therapeutics in Cancer Therapy: Past, Present, and Future. [PDF]

Int J Mol Sci
Vorona K, Ryapolova A, Sokolova O, Karabelsky A, Ivanov R, Reshetnikov V, Minskaia E.   +6 more
europepmc   +1 more source

Ultrasensitive Test Systems Are Required to Quantify Interferon Alpha Protein in Serum Samples. [PDF]

Eur J Immunol
Haljasmägi L, Meisalu S, Bondet V, Peterson P, Duffy D, Kisand K.   +5 more
europepmc   +1 more source

PEDV NSP8 inhibits IFN-III production induced by MAVS through downregulation of PEX13. [PDF]

mBio
Lou J, Zhu H, Yang Z, Jiang P, Liu G, Wang X.   +5 more
europepmc   +1 more source

Aging Reshapes γ/δ T-Cell Immunity Through a Type I Interferon-Foxo1 Axis. [PDF]

Aging Cell
Durand A, Porte S, Xing E, Wu C, Le Bon A, Auffray C, Lucas B, Martin B.   +7 more
europepmc   +1 more source

Leveraging human precision cut lung slices for the study of human parainfluenza virus 3 infection. [PDF]

Respir Res
Danov O, Vollmer Barbosa P, Obernolte H, Fuchs M, Guillon P, Dirr L, El-Deeb I, Kunz M, Hose L, Martin G, Röpken F, Zimmer A, Neubert L, Jonigk D, Fieguth HG, Dahlmann F, Wronski S, von Itzstein M, Tschernig T, Braun A, Sewald K.   +20 more
europepmc   +1 more source