Results 41 to 50 of about 101,532 (252)
Tutorial on the Robust Interior Point Method
CoRR, 2021 We give a short, self-contained proof of the interior point method and its robust version.
Yin Tat Lee, Santosh S. Vempala
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
A full Nesterov-Todd step interior-point method for circular cone optimization
Communications in Combinatorics and Optimization, 2016 In this paper, we present a full Newton step feasible interior-point method for circular cone optimization by using Euclidean Jordan algebra. The search direction is based on the Nesterov-Todd scaling scheme, and only full-Newton step is ...
Behrouz Kheirfam
doaj +1 more source
Energies, 2020 Flexible loads have flexibility and variability in time and space, and they have been widely studied by scholars. However, the research on the participation of flexible loads in market clearing and safety checking is still insufficient.
Dong Hua, Wutao Chen, Cong Zhang
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Journal of Applied Mathematics, 2013 Recently, various methods have been developed for solving linear programming problems with fuzzy number, such as simplex method and dual simplex method.
Yi-hua Zhong +3 more
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A recursive Riccati interior-point method for chance-constrained stochastic model predictive control
SICE Journal of Control, Measurement, and System Integration, 2023 This study covers the model predictive control of linear discrete-time systems subject to stochastic additive disturbances and state chance constraints.
Jingyu Zhang, Toshiyuki Ohtsuka
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