Results 51 to 60 of about 16,300,520 (272)
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
ElectricityThis paper addresses the optimal conductor selection (OCS) problem in radial distribution networks, aiming to minimize the total costs associated with conductor investment and energy losses while ensuring voltage regulation and power balance as well as ...
Oscar Danilo Montoya +2 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Abstract and Applied Analysis, 2012 A combined interior point homotopy continuation method is proposed for solving general multiobjective programming problem. We prove the existence and convergence of a smooth homotopy path from almost any interior initial interior point to a solution of ...
X. Zhao +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Solving large scale linear programming [PDF]
, 1993 The interior point method (IPM) is now well established as a competitive technique for solving very large scale linear programming problems. The leading variant of the interior point method is the primal dual - predictor corrector algorithm due to ...
Levkovitz, R, Mitra, G, Hafsteinsson, H
core +4 more sources
A new full-NT step interior-point method for circular cone optimization
Croatian Operational Research Review, 2019 We present a full step interior-point algorithm for circular coneoptimization using Euclidean Jordan algebras. The specificity of ourmethod is to use a transformation similar to that introduced byDarvay and Tak\'acs for the centering equations of the ...
Behrouz Kheirfam
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
A full Nesterov-Todd step interior-point method for circular cone optimization
Communications in Combinatorics and Optimization, 2016 In this paper, we present a full Newton step feasible interior-point method for circular cone optimization by using Euclidean Jordan algebra. The search direction is based on the Nesterov-Todd scaling scheme, and only full-Newton step is ...
Behrouz Kheirfam
doaj +1 more source