Results 51 to 60 of about 970,162 (283)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Exact Mixed-Integer Nonlinear Programming Formulation for Conductor Size Selection in Balanced Distribution Networks: Single and Multi-Objective Analyses

Electricity
This paper addresses the optimal conductor selection (OCS) problem in radial distribution networks, aiming to minimize the total costs associated with conductor investment and energy losses while ensuring voltage regulation and power balance as well as ...
Oscar Danilo Montoya, Luis Fernando Grisales-Noreña, Oscar David Florez-Cediel   +2 more
doaj   +1 more source

A new full-NT step interior-point method for circular cone optimization

Croatian Operational Research Review, 2019
We present a full step interior-point algorithm for circular coneoptimization using Euclidean Jordan algebras. The specificity of ourmethod is to use a transformation similar to that introduced byDarvay and Tak\'acs for the centering equations of the ...
Behrouz Kheirfam
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Interior Point Method for Solving Fuzzy Number Linear Programming Problems Using Linear Ranking Function

Journal of Applied Mathematics, 2013
Recently, various methods have been developed for solving linear programming problems with fuzzy number, such as simplex method and dual simplex method.
Yi-hua Zhong, Yan-lin Jia, Dandan Chen, Yan Yang   +3 more
doaj   +1 more source

A Novel Market Clearing and Safety Checking Method for Multi-Type Units That Considers Flexible Loads

Energies, 2020
Flexible loads have flexibility and variability in time and space, and they have been widely studied by scholars. However, the research on the participation of flexible loads in market clearing and safety checking is still insufficient.
Dong Hua, Wutao Chen, Cong Zhang
doaj   +1 more source

Solving the continuous nonlinear resource allocation problem with an interior point method

, 2013
Resource allocation problems are usually solved with specialized methods exploiting their general sparsity and problem-specific algebraic structure. We show that the sparsity structure alone yields a closed-form Newton search direction for the generic ...
Rohal, James J., Wright, Stephen E.
core   +1 more source