Results 41 to 50 of about 1,785,875 (332)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
MathematicsIn this paper, a new full-Newton step feasible interior-point method for convex quadratic programming is presented and analyzed. The idea behind this method is to replace the complementarity condition with a non-negative weight vector and use the ...
Yongsheng Rao +2 more
doaj +1 more source
Komputasi Aliran Daya Optimal Sistem Tenaga Skala Besar dengan Metode Primal Dual Interior Point
Jurnal Rekayasa Elektrika, 2016 This paper focuses on the use of Primal Dual Interior Point method in the analysis of optimal power flow. Optimal power flow analysis with Primal Dual Interior Point method then compared with Linear Programming Method using Matpower program.
Syafii Syafii, Ikhwannul Kadri Masrul
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Clarabel: An interior-point solver for conic programs with quadratic objectives [PDF]
Mathematical Programming ComputationWe present a general-purpose interior-point solver for convex optimization problems with conic constraints. Our method is based on a homogeneous embedding method originally developed for general monotone complementarity problems and more recently ...
Paul Goulart, Yuwen Chen
semanticscholar +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
On the simplex, interior-point and objective space approaches to multiobjective linear programming
Journal of Algorithms & Computational Technology, 2021 Most Multiple Objective Linear Programming (MOLP) algorithms working in the decision variable space, are based on the simplex algorithm or interior-point method of Linear Programming.
Paschal B Nyiam, Abdellah Salhi
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source