Results 41 to 50 of about 858,678 (186)
Exact Solution Methods for the $k$-item Quadratic Knapsack Problem
, 2016 The purpose of this paper is to solve the 0-1 $k$-item quadratic knapsack problem $(kQKP)$, a problem of maximizing a quadratic function subject to two linear constraints. We propose an exact method based on semidefinite optimization.
A Billionnet +18 more
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FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
An interior point algorithm for computing equilibria in economies with incomplete asset markets [PDF]
, 2004 Computing equilibria in general equilibria models with incomplete asset (GEI) markets is technically difficult. The standard numerical methods for computing these equilibria are based on homotopy methods.
Esteban-Bravo, Mercedes
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FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Finding a point in the relative interior of a polyhedron [PDF]
, 2007 A new initialization or `Phase I' strategy for feasible interior point methods for linear programming is proposed that computes a point on the primal-dual central path associated with the linear program. Provided there exist primal-dual strictly feasible
Cartis, Coralia, Gould, Nicholas I. M.
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Crash start of interior point methods [PDF]
European Journal of Operational Research, 2016 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Interior Point Methods with a Gradient Oracle
Proceedings of the 55th Annual ACM Symposium on Theory of Computing, 2023 We provide an interior point method based on quasi-Newton iterations, which only requires first-order access to a strongly self-concordant barrier function. To achieve this, we extend the techniques of Dunagan-Harvey [STOC '07] to maintain a preconditioner, while using only first-order information. We measure the quality of this preconditioner in terms
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Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
A comparison of general-purpose optimization algorithms forfinding optimal approximate experimental designs [PDF]
, 2019 Several common general purpose optimization algorithms are compared for findingA- and D-optimal designs for different types of statistical models of varying complexity,including high dimensional models with five and more factors.
Garcia-Garcia, Jose Carlos +4 more
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