Results 61 to 70 of about 16,527,400 (269)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

A Comparative Study of Applying Active-Set and Interior Point Methods in MPC for Controlling Nonlinear pH Process

open access: yesJurnal Rekayasa Kimia & Lingkungan, 2014
A comparative study of Model Predictive Control (MPC) using active-set method and interior point methods is proposed as a control technique for highly non-linear pH process. The process is a strong acid-strong base system.
Syam Syafiie, Chia Yaw Kwan
doaj   +1 more source

Interior-point methods for PDE-constrained optimization [PDF]

open access: yes, 2013
In applied sciences PDEs model an extensive variety of phenomena. Typically the final goal of simulations is a system which is optimal in a certain sense. For instance optimal control problems identify a control to steer a system towards a desired state.
Huber, Johannes
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

open access: yesFEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose   +9 more
wiley   +1 more source

An Interior-Point algorithm for Nonlinear Minimax Problems [PDF]

open access: yes
We present a primal-dual interior-point method for constrained nonlinear, discrete minimax problems where the objective functions and constraints are not necessarily convex.
E. Obasanjo, G. Tzallas-Regas, B. Rustem
core  

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

Crash start of interior point methods [PDF]

open access: yesEuropean Journal of Operational Research, 2016
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +4 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

open access: yesFEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana   +5 more
wiley   +1 more source

Interior/exterior point methods with inertia correction for the solution of the reactive optimal power flow problem with discrete variables

open access: yesGEPROS: Gestão da Produção, Operações e Sistemas, 2018
Interior and Exterior Points Methods have been used for solving the Optimal Reactive Power Flow (ORPF) problem. However, the solution of the the ORPF problem is hampered when transformers tap ratios and the shunts of capacitor banks and reactors are ...
Leonardo Nepomuceno   +1 more
doaj   +1 more source

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