Results 61 to 70 of about 1,050,523 (298)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

SupaVenezia From SupaStore: Between Art, Commerce, and Spatial Dynamics

open access: yesInteriority
This exhibition review reflects on the spatial and curatorial concepts, interior spatial qualities, and precedent design processes of SupaVenezia, which was held at the A plus A Gallery in Venice from 31 August to 25 September 2022.
Ayman Kassem
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

open access: yesMolecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir   +9 more
wiley   +1 more source

Interior Design 3D Printing Mistakes and Best Practices: A Case Study of a Retail Shop [PDF]

open access: yes
In the realm of interior and architectural design, the significance of three‐dimensional awareness is undeniable. However, this industry's demand for physical modeling has notably declined.
Wickremasinghe, Madara, Cho, Yongyeon
core  

Ökompakt 50 - ventilator with heat regenerate [PDF]

open access: yesActa Montanistica Slovaca, 2000
In the paper presents ventilator with heat regenerate. The apparaturs are manufactured by f. Hölter, GmbH, and it patent schould. The quality aur in interier is on line relation to different alergical disease (Sick Building Syndrom - SBS).Ventilator with
Heinz Hölter
doaj  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Peculiarities of Operator Shooting of Television Programs in Interiors

open access: yesВісник Київського національного університету культури і мистецтв. Серія: Аудіовізуальне мистецтво і виробництво
The purpose of the research is to examine the distinctive characteristics of the process of filming television programmes in the interior and their impact on visual art and audience perception.
Баталіна Христина   +1 more
doaj   +1 more source

THE SPECIFICS OF POSTEMBUONIC BIOGENESIS OF VISTAR WHITE MICE UNDER THE EFFECT OF NITROUS OXIDES

open access: yesНаука. Инновации. Технологии, 2022
The article presents the data on the growth and development of Vistar white mice, their hematologis indices and natural resistance in the conditions of nitrous oxides effect.
Viktor Mikhailovich Ivanov
doaj  

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