Results 111 to 120 of about 847,053 (257)
Advanced Science, EarlyView.Pathological tissue rigidity mechanoprimes microglia by enhancing actin cytoskeleton–nucleus coupling and chromatin opening at rigidity‐responsive cis‐regulatory elements (mechanoCREs). Subsequent NF‐κB/p65 signaling converges on this permissive regulatory state to amplify inflammatory gene expression and microglial activation.
Yu Xuan Meng +15 more
wiley +1 more source
Planetary formation tracks on the Hertzsprung–Russell diagram
Astronomy & AstrophysicsContext. The Hertzsprung-Russell diagram (HRD) has long served as a cornerstone of astrophysics, illustrating the relationship between stellar luminosity and effective temperature.
Gottstein Benedikt +2 more
doaj +1 more source
Predicting Enzyme Turnover Numbers and Enabling Rational Enzyme Evolution
Advanced Science, EarlyView.MCKcat, a deep learning framework combining multi‐scale convolution and cross‐attention, accurately predicts enzyme turnover number (kcat) by fusing sequence and reaction representations. It couples with rational design in a two‐step strategy for Bacillus aryabhattai laccase engineering, achieving a 75% positive rate with synergistically enhanced ...
Fengya Ge +6 more
wiley +1 more source
Carleman estimates for degenerate parabolic equations with single interior point degeneracy and its applications [PDF]
We study the controllability of a class of $N$-dimensional degenerate parabolic equations with single interior point degeneracy. We employ the Galerkin method to prove the existence of solutions for the equations.
Hu, Yaozhong +3 more
core +1 more source
Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications
Advanced Science, EarlyView.Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen +11 more
wiley +1 more source
Phlegethon: a fully compressible magnetohydrodynamic code for simulations in stellar astrophysics
The Open Journal of AstrophysicsWe present PHLEGETHON, a fully compressible, Eulerian magnetohydrodynamic (MHD) code designed for multidimensional simulations in stellar astrophysics. The code uses a time-explicit, second-order, finite-volume method optimized to model a wide range of ...
G. Leidi +14 more
doaj +1 more source
Advanced Science, EarlyView.Adult human organotypic cortical slices undergo marked neuronal loss, laminar disruption, and glial activation, yet their network activity progressively stabilizes after a variable period. Electrophysiology, longitudinal calcium imaging, and quantitative histology show that structurally remodeled human circuits show adaptive capacity resulting in ...
Estilla Zsófia Tóth +20 more
wiley +1 more source
Advanced Science, EarlyView.An injectable, self‐healing COPRP hydrogel integrates structurally defined oxidized Polygonati rhizoma polysaccharide with carboxymethyl chitosan through dynamic Schiff‐base crosslinking. The bioactive matrix scavenges reactive oxygen species, suppresses neuroinflammation, protects dopaminergic neurons, and supports sustained levodopa release.
Peng Dai +10 more
wiley +1 more source
Degeneracy, its causes, signs, and results
, 1898 DEGENERACY, ITS CAUSES, SIGNS, AND RESULTS Degeneracy, its causes, signs, and results (-
Talbot, Eugene
core +2 more sources