Results 31 to 40 of about 141,195 (252)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Abstract and Applied Analysis, 2012 A combined interior point homotopy continuation method is proposed for solving general multiobjective programming problem. We prove the existence and convergence of a smooth homotopy path from almost any interior initial interior point to a solution of ...
X. Zhao +3 more
doaj +1 more source
Counting the Interior Points of a Point Configuration [PDF]
Discrete & Computational Geometry, 2000 Let \(A\) be a collection of points in \(\mathbb{R}^d\) whose affine span is \(\mathbb{R}^d\), and \(\text{int}(A)\) the set of points in \(A\) that lie in the interior of its convex hull \(\text{conv}(A)\). A subset \(K\subseteq A\) is called free if \(\text{conv} (K)\cap A=K\) and the set of vertices of \(\text{conv}(K)\) is \(K\).
Edelman, P. H., Reiner, V.
openaire +2 more sources
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Interior point methods in the year 2025
EURO Journal on Computational OptimizationInterior point methods (IPMs) have hugely influenced the field of optimization. Their fast development has been triggered by the seminal paper of Narendra Karmarkar published in 1984 which delivered a polynomial algorithm for linear programming and ...
Jacek Gondzio
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
A New Hybrid Preconditioner for the Interior Point Method
Trends in Computational and Applied Mathematics, 2019 This study aims to improve the computation of the search direction in the primal-dual Interior Point Method through preconditioned iterative methods. It is about a hybrid approach that combines the Controlled Cholesky Factorization preconditioner and ...
Manolo Rodriguez Heredia +2 more
doaj +1 more source
IMPROVING AUTOMATIC RECONSTRUCTION OF INTERIOR WALLS FROM POINT CLOUD DATA [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2019 In this paper we deal with the automatic reconstruction of interior walls from point clouds, an active research topic with several practical applications.
E. Maset, L. Magri, A. Fusiello
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source