Results 51 to 60 of about 1,515,221 (275)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
A New Hybrid Preconditioner for the Interior Point Method
Trends in Computational and Applied Mathematics, 2019 This study aims to improve the computation of the search direction in the primal-dual Interior Point Method through preconditioned iterative methods. It is about a hybrid approach that combines the Controlled Cholesky Factorization preconditioner and ...
Manolo Rodriguez Heredia +2 more
doaj +1 more source
On $k$-point configuration sets with nonempty interior
, 2020 We give conditions for $k$-point configuration sets of thin sets to have nonempty interior, applicable to a wide variety of configurations. This is a continuation of our earlier work \cite{GIT19} on 2-point configurations, extending a theorem of Mattila ...
Greenleaf, Allan +2 more
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Interior-point algorithms for a class of convex optimization problems [PDF]
Yugoslav Journal of Operations Research, 2009 In this paper we consider interior-point methods (IPM) for the nonlinear, convex optimization problem where the objective function is a weighted sum of reciprocals of variables subject to linear constraints (SOR).
Lešaja Goran, Slaughter Verlynda N.
doaj +1 more source
BUILDING ENVELOPE AND INTERIOR GRADING SYSTEMS AND METHODS [PDF]
, 2019 A difference module determines differences between an outdoor ambient temperature and an indoor temperature, determines a first average of the differences , and determines a second average of the differences.
Alsaleem, Fadi Mohammad
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Interior point control and observation for the wave equation
Abstract and Applied Analysis, 1996 This paper is concerned with the approximate and exact controllability properties of the wave equation with interior point controls entering via the concentrated force, the velocity of the displacement and the moment.
A. Y. Khapalov
doaj +1 more source
The group approach to AdS space propagators
, 2003 We show that AdS two-point functions can be obtained by connecting two points in the interior of AdS space with one point on its boundary by a dual pair of Dobrev's boundary-to-bulk intertwiners and integrating over the boundary point.Comment: 23 ...
Allen +18 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source