Results 61 to 70 of about 112,928 (251)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Interior Point Method for Solving Fuzzy Number Linear Programming Problems Using Linear Ranking Function

Journal of Applied Mathematics, 2013
Recently, various methods have been developed for solving linear programming problems with fuzzy number, such as simplex method and dual simplex method.
Yi-hua Zhong, Yan-lin Jia, Dandan Chen, Yan Yang   +3 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Short run hydrothermal coordination with network constraints using an interior point method

Ingeniería y Ciencia, 2008
This paper presents a lineal optimization model to solve the hydrothermal coordination problem. The main contribution of this work is the inclusion of the network constraints to the hydrothermal coordination problem and its solution using an interior ...
Jesús María López Lezama, Luis Alfonso Gallego Pareja, Diego Mejía Giraldo   +2 more
doaj  

An improved search direction based on algebraic equivalent transformation technique for convex quadratic optimization [PDF]

Iranian Journal of Numerical Analysis and Optimization
This work presents an improved interior point algorithm with full Newton step for convex quadratic optimization. Based on the technique of algebraic equivalent transformation, we first propose a new search direction for convex quadratic optimization with
Aicha Kraria, Bachir Merikhi, Djamel Benterki   +2 more
doaj   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

An efficient algorithm for the projection of a point on the intersection of two hyperplanes and a box in Rn

EURO Journal on Computational Optimization, 2019
In this work, Rn we present an efficient strongly polynomial algorithm for the projection of a point on the intersection of two hyperplanes and a box in Rn.
CláudioP. Santiago, Sérgio Assunção Monteiro, Helder Inácio, Nelson Maculan, MariaHelena Jardim   +4 more
doaj   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

A numerical study of an infeasible interior-point algorithm for convex quadratic semi-definite optimization

Journal of Numerical Analysis and Approximation Theory
The focus of this research is to apply primal-dual interior-point pathfollowing methods, specifically those derived from Newton’s method for solving convex quadratic semidefinite optimization (CQSDO) problems. In this paper, we present a numerical study
Yasmina Bendaas, Mohamed Achache
doaj   +1 more source