Results 111 to 120 of about 24,572,041 (402)
Biology of the Interleukin-1 Receptor
Journal of Investigative Dermatology, 1990 The biological effects of the two interleukin-1s on cells of connective tissue origin are mediated by specific cell-surface receptors. Molecular cloning studies have revealed that these receptors are identical in protein sequence to the IL-1 receptors on cells of the T-lymphocyte lineage. The functional interleukin-1 receptor on T-cells and fibroblasts
Rebecca A. Blanton +7 more
openaire +3 more sources
Letter by Takahashi regarding article "targeting interleukin-1 in heart disease".
Circulation, 2014 I read with great interest the article by Van Tassell et al1 in which the authors thoroughly reviewed the role of interleukin-1 in heart disease. They discuss cardiovascular sterile inflammation and refer to the inflammasome as the related mechanism that
Masafumi Takahashi
semanticscholar +1 more source
The role of circular RNAs in regulating cytokine signaling in cancer
FEBS Open Bio, EarlyView.Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi +4 more
wiley +1 more source
Investigation of interleukin-1 alpha and interleukin-6 expression and interleukin-1 alpha gene polymorphism in keratocystic odontogenic tumors and ameloblastomas [PDF]
, 2011 Objective: In jawbones, ameloblastomas and odontogenic keratocysts share many clinical features in common such as aggressiveness, high recurrence rates and radical management options.
Oygür, Tüllin, Sengüven, Burcu
core +1 more source
Italian Journal of Animal Science, 2019 The current study was conducted to examine the pre-protection effects of vitamin A (VA) on lipopolysaccharide (LPS)-induced oxidative damage in bovine mammary epithelial cells (BMECs) and to explore the antioxidant mechanisms of VA via nuclear factor ...
Huiyu Shi +5 more
doaj +1 more source
Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America, 1989 Interleukin 1, an immune response-generated cytokine that stimulates astrocyte proliferation and reactivity (astrogliosis), was present in up to 30 times as many glial cells in tissue sections of brain from patients with Down syndrome and Alzheimer ...
W. Sue +9 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley +1 more source
Interleukin-1 receptor-associated kinase and TRAF-6 mediate the transcriptional regulation of interleukin-2 by interleukin-1 via NFκB but unlike interleukin-1 are unable to stabilise interleukin-2 mRNA [PDF]
, 1999 Interleukin-1 receptor-associated kinase, IRAK, has been shown to activate NFκB in response to interleukin-1. We have explored the involvement of IRAK in regulation of the interleukin-2 gene in the murine thymoma cell line EL4.NOB-1 by examining its ...
Greene, Catherine, O’Neill, Luke
core +1 more source
Interleukin-1 and the mesangial cell
Kidney International, 1992 Interleukin-1 (IL-1) is a proinflammatory cytokine which was originally described as a product of activated mononuclear phagocytes, but is now known to be released by many cell types. Systemically, IL-1 induces fever, the acute phase response, and neutrophilia. Locally it mediates tissue injury and remodelling by inducing cells to undergo a coordinated
John R. Sedor +2 more
openaire +3 more sources
Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies
Aging and Cancer, EarlyView.This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal +8 more
wiley +1 more source