Diverse Treatment Goals in Psoriatic Arthritis: Insights From Participants in the PARC Cohort
Arthritis Care &Research, EarlyView.Objective The aim of this study was to examine patient‐reported treatment goals among individuals with psoriatic arthritis. Methods Participants in the Psoriatic Arthritis Research Consortium completed standardized assessments, including patient‐reported outcome (PROs) instruments, between 2017 and 2020.
Astia Allenzara +8 more
wiley +1 more source
Interleukin-1 Receptor antagonist Production by Human Keratinocytes [PDF]
, 1992 Human keratinocytes produce biologically active pro–IL-Iα and inactive pro-IL-1β with most protein remaining intracellular. IL-1 receptor antagonist (IL-1ra) is a newly described member of the IL-1 family that is secreted by stimulated monocytes and ...
Arend, William P +3 more
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Monocyte-conditioned medium, interleukin-1, and tumor necrosis factor stimulate the acute phase response in human hepatoma cells in vitro. [PDF]
, 1986 G.J. Darlington +2 more
openalex +1 more source
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.
Genes & Development, 1999 Bone resorption and remodeling is an intricately controlled, physiological process that requires the function of osteoclasts. The processes governing both the differentiation and activation of osteoclasts involve signals induced by osteoprotegerin ligand
M. Lomaga +22 more
semanticscholar +1 more source
Metabolic Consequences of Rheumatoid Arthritis
Arthritis Care &Research, EarlyView.Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry +2 more
wiley +1 more source
Enhanced release of elastase is not concomitant with increased secretion of granulocyte-activating cytokines in whole blood from patients with sepsis [PDF]
, 1994 Die Diskussion am Ende des Artikels wurde gelöscht (§137l UrhG).Background The proteolytic enzyme elastase released by granulocytes (polymorphonuclear leukocytes [PMN]) in high concentrations during sepsis causes degradation of essential plasma proteins,
Ertel, Wolfgang +6 more
core +1 more source
International Journal of COPD, 2017 Katherine J Baines,1,2 Juan-juan Fu,3 Vanessa M McDonald,1,2 Peter G Gibson1,2 1Faculty of Health and Medicine, Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, The University of Newcastle, 2Department of Respiratory and ...
Baines KJ, Fu JJ, McDonald VM, Gibson PG
doaj
Osteoarthrosis or osteoarthritis? A current view of the disease and its treatment
Современная ревматология, 2013 The paper gives an update on the pathogenesis of osteoarthrosis, the role of anti-inflammatory cytokines in the destruction of cartilage and subchondral bone, and the possibility of targeted diacerein therapy.
Rimma Mikhailovna Balabanova
doaj +1 more source
Mode of fibroblast growth enhancement by human interleukin-1. [PDF]
, 1988 J P Singh +2 more
openalex +1 more source
Interleukin-1, interleukin-1 receptor, and interleukin-1 receptor antagonist [PDF]
Proceedings of the Nutrition Society, 1994 Edward M. Copeland +3 more
openaire +2 more sources