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Immunology Today, 1989
The diverse biological activities of interleukin 1 (IL-1) have attracted interest from a wide range of biological disciplines ~ After systemic injection into a variety of animals, it seems that IL-1 affects nearly every organ system. Interested parties fall into two groups: those studying the potential beneficial effects of IL-1 on host defense ...
C A, Dinarello +4 more
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The diverse biological activities of interleukin 1 (IL-1) have attracted interest from a wide range of biological disciplines ~ After systemic injection into a variety of animals, it seems that IL-1 affects nearly every organ system. Interested parties fall into two groups: those studying the potential beneficial effects of IL-1 on host defense ...
C A, Dinarello +4 more
openaire +2 more sources
Interleukin-1 and interleukin-1 receptor antagonist.
Nutrition (Burbank, Los Angeles County, Calif.), 1996Cytokines are produced in disease or during immunologic challenge. Some cytokines increase host resistance to disease whereas others trigger inflammatory processes. Interleukin 1 (IL-1) and tumor necrosis factor (TNF) are pro-inflammatory cytokines that affect nearly every cell either alone or in a synergistic fashion.
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Immunological and inflammatory functions of the interleukin-1 family.
Annual Review of Immunology, 2009C. Dinarello
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Interleukin-1 and hematopoiesis
Blood Reviews, 1989Interleukin-1 alpha and interleukin-1 beta are 17.5 kDa peptides which exert a wide variety of biological activities. Both forms of interleukin bind to a common 60-70 kDa receptor expressed by most somatic cells. One major effect of interleukin-1 is to induce the expression of other genes, including genes for other interleukins (IL-6), colony ...
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Interleukin-1 signal transduction
International Journal of Clinical and Laboratory Research, 1995Interleukin 1 (IL1) is a potent pro-inflammatory cytokine which has been implicated in the pathogenesis of chronic inflammatory disease. Despite much effect, the signal transduction pathway activated by IL1 has remained obscure. Recently, much attention has focussed on IL1 receptors and early events triggered by IL1 in cells, including activation of ...
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The interleukin-1/interleukin-1-receptor interaction
Annales de l'Institut Pasteur / Immunologie, 1987H R, MacDonald, J W, Lowenthal
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