Results 361 to 370 of about 24,572,041 (402)
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Brain macrophages synthesize interleukin‐1 and interleukin‐1 mRNAs in vitro
Journal of Neuroscience Research, 1988AbstractAmoeboid microglial cells (brain macrophages) were purified from early post‐natal mouse brain cultures. The percentage of cells stained with an anti‐Mac‐1 antibody was > 95%. Stimulation of these brain macrophages by lipopolysaccharides induced the synthesis of interleukin‐1 (IL‐1), which, in part, remained associated with the cell surface ...
Anne Bousseau +6 more
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Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor
Nature, 1990Three interleukin-1 inhibitors have been purified to homogeneity from medium conditioned by human monocytes. Partial sequence analysis and digestion with N-glycanase indicate that these are glycosylation forms of a single protein. The protein binds to the interleukin-1 receptor but has no interleukin-1-like activity, even at very high concentrations ...
Patricia L. Heimdal +9 more
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Expression of interleukin-1 and interleukin-1 receptor antagonists in endometrial cancer
Gynecologic Oncology, 1991The cytokine interleukin-1 (IL-1) can inhibit growth of breast cancer cells in culture and promote cellular differentiation in synergism with other growth factors. A secreted IL-1 receptor antagonist (sIL-1ra) has been described and an intracellular version (icIL-1ra) has been cloned; both antagonists block IL-1-dependent responses.
W.C. Fowler +7 more
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Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor.
Science, 1987There is now evidence that the immune system, during times of infectious challenge, can stimulate the secretion of glucocorticoids, the adrenal steroids that mediate important aspects of the response to stress.
R. Sapolsky +4 more
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Interleukin‐1 and interleukin‐1 receptor antagonist in inflammatory bowel disease.
Alimentary Pharmacology & Therapeutics, 1996Ulcerative colitis (UC) and Crohn's disease (CD) are immunologically mediated disorders characterized by a chronic, relapsing inflammatory response. Elevation of several cytokines, with important immunoregulatory and proinflammatory activities have been demonstrated during active inflammatory bowel disease (IBD).
Theresa T. Pizarro, Fabio Cominelli
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Interleukin-1 and inflammatory neurodegeneration
Biochemical Society Transactions, 2007Inflammation occurs rapidly in response to acute brain insults such as stroke, haemorrhage or trauma, and can be sustained for long periods of time, for example in Alzheimer's or Parkinson's diseases and multiple sclerosis. Experimental evidence indicates that inflammation plays a major role in neurodegeneration under these conditions, and that the ...
Simi, A. +3 more
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Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones.
Science, 1986The production and action of immunoregulatory cytokines, including interleukin-1 (IL-1), are inhibited by glucocorticoid hormones in vivo and in vitro. Conversely, glucocorticoid blood levels were increased by factors released by human leukocytes exposed
H. Besedovsky +3 more
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The interleukin-1/interleukin-1-receptor interaction
Annales de l'Institut Pasteur / Immunologie, 1987J.W. Lowenthal, H.R. MacDonald
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Interferons as inhibitors of interleukin 1 induced interleukin 1 synthesis.
Lymphokine research, 1989IL-1 induces its own gene expression in cultured smooth muscle and endothelial cells and in human PBMC. IL-1-induced IL-1 may be part of a self-amplification or autocrine event in inflammation. In the present study IFN gamma consistently increased LPS-induced IL-1, but reduced the total amount of IL-1-induced IL-1 from PBMC. On a molar basis, IFN gamma
Schindler, R, Ghezzi, P, Dinarello, C A
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