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Targeted Therapy with a Novel Superantigen-based Fusion Protein Against Interleukin-13 Receptor α2-overexpressing Tumor Cells: An In-silico Study. [PDF]
Iran J PatholGholipour Z +2 more
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Advanced Science, EarlyView.Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang +16 more
wiley +1 more source
Comparative safety analysis of anti-interleukin-4/interleukin-13 inhibitors and Janus Kinase inhibitors in atopic dermatitis. [PDF]
J Am Acad DermatolBao A, Su HJ, Wan J.
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Current Opinion in Pulmonary Medicine, 2003
Some time ago, the Th2 cytokine, interleukin (IL)-13, was identified as a critical regulator of the allergic response. Initial studies in animal models of disease provided compelling evidence that IL-13, independent from other Th2 cytokines, was necessary and sufficient to induce all features of allergic asthma.
Marsha, Wills-Karp, Monica, Chiaramonte
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Some time ago, the Th2 cytokine, interleukin (IL)-13, was identified as a critical regulator of the allergic response. Initial studies in animal models of disease provided compelling evidence that IL-13, independent from other Th2 cytokines, was necessary and sufficient to induce all features of allergic asthma.
Marsha, Wills-Karp, Monica, Chiaramonte
openaire +2 more sources
Current Protocols in Immunology, 2001
AbstractThis unit describes two protocols that can be used to quantitate interleukin‐13 (IL‐13). The enzyme‐linked immunosorbent assay (ELISA) has the advantage of being highly specific for human IL‐13 and does not recognize other cytokines present in the sample.
Angus, Lauder, Andrew N J, McKenzie
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AbstractThis unit describes two protocols that can be used to quantitate interleukin‐13 (IL‐13). The enzyme‐linked immunosorbent assay (ELISA) has the advantage of being highly specific for human IL‐13 and does not recognize other cytokines present in the sample.
Angus, Lauder, Andrew N J, McKenzie
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[Interleukin 13 and interleukin 13 receptor involvement in systemic sclerosis].
La Revue de medecine interne, 2007Interleukin 13 is an immunoregulatory cytokine predominantly secreted by activated Th2 cells. It has similar functions with interleukin 4 and they share a common receptor. However, unlike interleukin 4, l'interleukin 13 does not appear to be important in the initial differentiation of CD4 T into Th2-type cells, but rather appears to be necessary in the
Granel, B., Chevillard, C., Dessein, A.
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Interleukin-13 in asthma pathogenesis
Current Allergy and Asthma Reports, 2004Summary: Bronchial asthma is a complex disorder that is thought to arise as a result of aberrant T‐lymphocyte responses to noninfectious environmental antigens. In particular, the symptoms of asthma are closely associated with the presence of activated T‐helper 2 cell (Th2) cytokine‐producing cells [interleukin (IL)‐4, IL‐5, IL‐9, and IL‐13] in the ...
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International Journal of Rheumatic Diseases, 2021
AbstractAim of the workTo identify the role of serum IL‐13, and its receptor subunit expressions as a serologic marker of rheumatoid arthritis (RA)‐associated ILD (RA‐ILD).Patients and MethodsFifty RA patients with ILD and 50 RA patients without ILD were examined, in addition to 50 controls.
Manal Shawky Hussein +5 more
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AbstractAim of the workTo identify the role of serum IL‐13, and its receptor subunit expressions as a serologic marker of rheumatoid arthritis (RA)‐associated ILD (RA‐ILD).Patients and MethodsFifty RA patients with ILD and 50 RA patients without ILD were examined, in addition to 50 controls.
Manal Shawky Hussein +5 more
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Interleukin-13 and Leukotrienes
American Journal of Respiratory Cell and Molecular Biology, 2003The episodic wheezing and shortness of breath caused by events in asthma, have not been extensively investigated. In this issue of the AJRCMB, Vargaftig and Singer address asthma has been recognized since antiquity. As a result, major efforts have been directed at studies of asthma pathothis gap in our knowledge and demonstrate, for the first time ...
Jack A, Elias +4 more
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